1297 Death of Joannes. His son Alexius II succeeds at age of fifteen. He soon frees himself from his guardian, Andronicus II of Constantinople.
1302 Alexius repels a Turkoman invasion in a great battle near Kerasunt.
1310 After many trade disputes with the Genoese establishments on the Black Sea, Genoa demands a favourable treaty with Alexius, which he refuses. The enraged Genoese burn a portion of Trebizond, but fear of the Venetians compels them to agree to trading on the old terms.
1314 Sinopian pirates set fire to Trebizond and much damage is done.
1330 Death of Alexius. His eldest son, Andronicus III, succeeds. A period of anarchy and civil war begins. Andronicus supposed to have put two brothers to death. Another brother and an uncle flee to Constantinople.
1332 Death of Andronicus. Accession of his young son, Manuel II, with everyone in power attempting to gain the direction of affairs. Taking advantage of the condition of affairs the Turkomans invade the empire, which is in great danger, and Basil, the fugitive son of Alexius II, is invited to become emperor. Manuel deposed. Basil proves a profligate monarch, and marries his mistress in spite of the fact that he has a wife. The power becomes decentralised.
1340 Death of Basil. His lawful wife, Irene Palæologina, daughter of the Byzantine emperor, is placed on the throne by her adherents. Civil war breaks out.
1341 Anna Anachoulu, daughter of Alexius II, is placed by the Comnenian party on the throne. Irene deposed. Michael, second son of Joannes II, claims throne. He is imprisoned, but a party forms around his son, Joannes.
1342 Joannes III gains throne from Anna. She is strangled.