147 The province of Babylonia is wrested from the Seleucids. The East is finally lost to the Macedonians.
139 Capture of Demetrius II of Syria, who has attempted to establish himself in Mesopotamia.
138 Successful campaign in Elymais. Death of Mithridates. He has made Parthia a great power. His son, Phraates II or Arsaces (VI) Euergetes, succeeds. He adds Margiana to the kingdom. The seat of the kingdom is transferred to Media.
130 Antiochus Sidetes begins a vigorous campaign against the Parthians, whom he defeats in a great battle on the Upper Zab. Babylon and Ecbatana are recovered.
129 The Parthians make secret terms with the Medes and attack Antiochus, whose host is annihilated and he himself slain. Phraates compelled to attack the Scythians, whom he had invited to assist him against Antiochus. They have arrived too late, and, as Phraates refuses to pay them, they begin to ravage the country.
128 Death of Phraates in a disastrous battle with the Scythians. His uncle, Artabanus I or Arsaces (VII) Nicator, son of Phriapatius, succeeds. The Scythians withdraw, content with their victory; Artabanus pays them tribute. There appear to have been rival kings in this and the following reign. Perhaps they are Scythians. The usurpers are suppressed. Artabanus dies (date unknown), after a short reign, in battle with the Tochari, and is succeeded by his son, Mithridates (II) the Great or Arsaces (VIII) Theos Euergetes. He wages many wars, and wins victories from the Scythians. Lost territory is recovered. The Euphrates is fixed as the western boundary of the kingdom.
94 Mithridates puts Tigranes II on the disputed throne of Greater Armenia.
92 Sulla, proprætor of Cilicia, meets the ambassador of Mithridates on the Euphrates, seeking the Roman alliance in some connection with the Parthian schemes against Syria. First contact of Parthia with Rome. Mithridates at war with Laodice, queen of Commagene.
88 About this date Mithridates captures Demetrius III and his army, dies shortly afterwards, and is succeeded by Artabanus II or Arsaces IX. He is the last to bear title “king of kings,” which passes to Tigranes II of Armenia.
77 Sinatruces or Arsaces (X) Autocrator, an exile living with the Scythian tribe of the Sacarances, is placed on the throne at the age of eighty. Continual wars with Tigranes, who conquers Media, ravages Arbela and Nineveh, and compels the cession of Adiabene and Nisibis.