350 Sapor almost succeeds in capturing Nisibis when troubles with the barbarians in the East compel him to raise the siege.
350-358 War in the East causes almost complete suspension in the conflict with Rome.
358 Peace made in the East and Romans sue for peace. Sapor declines and war is continued.
359 Sapor captures Amida, but the Romans regain it the following year. Hostilities are suspended until
363 when the emperor Julian attempts to strike a death-blow at Sapor. He takes Seleucia but fails to capture Ctesiphon. Death of Julian in battle. His successor Jovian makes a shameful peace with Sapor, granting him the lands east of the Tigris, and part of Mesopotamia with Nisibis and Singara. The Romans also agree not to help Arsaces of Armenia, and Sapor proceeds against him.
365-366 Reduction of Armenia and Iberia by Sapor.
371 The Romans attempt to recover Armenia, but fail through breaking out of the Gothic war.
379 Death of Sapor, succeeded by his brother Ardashir II.
383 or 384 Ardashir deposed by the nobles towards whom he has been very severe. Shapur or Sapor III, probably a son of Sapor II, raised to the throne. He makes a definite treaty of peace with Rome.
388 or 389 Murder of Sapor by the nobles. His brother (or perhaps son) Bahram or Varanes III succeeds.