1531 Daman taken and destroyed by Portuguese. Sousa founds São Vicente in Brazil and receives a grant of the first hereditary captaincy, or governorship of a province, in Brazil.
1536 Inquisition established in Portugal.
1539 Bishopric established at Goa.
1541 St. Francis Xavier sent to the Indies. Estevão da Gama, governor of India, leads an expedition to the Red Sea.
1542 Japan discovered by Fernão Mendes Pinto.
1543 Xavier founds Christian settlements in Travancore.
1545 The Indian viceroy De Castro wins victory of Diu over the king of Guzerat.
1548 St. Francis Xavier goes to Japan.
1549 Thomé de Sousa first governor-general of Brazil. He founds Bahia and governs by aid of Jesuits.
1557 Factories established at Macao. João III dies, and is succeeded by his three-year-old grandson Sebastian, under the regency of his grandmother Catherine and his great-uncle Cardinal Henry, but under the power of the brothers Camara.