1501 Bâle and Schaffhausen (the eleventh and twelfth members) are admitted to the confederation.
1510 Schinner, bishop of Sitten, induces Swiss troops to aid in the expulsion of the French from Italy.
1512 The Swiss conquer Milan and drive the French out of Italy; declare Maximilian duke of Milan. In return the confederates receive Ticino and the Grisons leagues get the Valtellina, Cleves, and Bormio.
The Confederation of Thirteen States
1513 Appenzell is admitted to the confederation, thus completing the confederation of Thirteen States. The Swiss defeat the French at Novara.
1515 Francis I defeats the Swiss at Marignano, breaking the Swiss power in northern Italy.
1516 The Swiss League concludes a treaty of Perpetual Peace with France. Hans Holbein at Bâle wins great reputation as a painter. His work marks the further advance of humanism in Switzerland.
1519 Ulrich (Huldreich) Zwingli preaches the Reformation at Zurich.
1521 Twelve states of the confederation (Zurich being restrained by Zwingli) conclude an alliance with France.
1522 The diet at Lucerne forbids the clergy to preach unauthorised doctrines.