Cohnheim, Julius. B. 1839, at Demmin, Pomerania; d. Aug. 14, 1884. Leipsig University Path. Institute. M.D. Berlin (Univs. Berlin, Wurzburg, Greifswald, and Prague); Assist. to Virchow at Path. Inst. Berlin, 1864; Prof. Path. Anat. at Kiel, 1868; Prof. Path. Anat. at Breslau, 1872, where was founded under his direction a new Pathological Institute. Accepted the Professorship of Gen. Path. and Anatomy at Leipsic, 1876.
Author of numerous articles in Medical Journals, “Lectures on General Pathology,” 1871; joint author with Dr. Anton von Schultheis Rechberg, of Zurich, of “Ueber die Folgen der Kranzarterienverschliessung für das Herz.”
Made experiments, in conjunction with Prof. Roy (whom see) “to elucidate a number of questions bearing upon the relation which exists between certain diseases of the kidney and cardiac hypertrophy.”
“If we now try to explain the striking phenomena which so invariably accompany our experiments, it is quite impossible not to conclude from the outset that they are the result of the closing of the coronary artery. It is quite true that less frequent beating of the heart, and even irregularities of the pulse, may occur spontaneously, and certainly without ligature of the coronary artery. Any one who has made frequent experiments on dogs in which the pressure of the blood has been noted down during a long period, knows very well that intermittent pulsation, and even greater irregularities, are not unfrequent occurrences in narcotised and bound or curarised animals—irregularities which disappear or re-appear, as the case may be. But the sudden ceasing of the diastolic beating of the heart may also occasionally be observed in dogs whose coronary arteries have not been touched. However, this only happens spontaneously (according to our experience) in dogs which have already been used for a long succession of experiments, which have resulted in the natural alteration of the action of the heart, and in whom the arterial pressure has been lowered to a great degree, more especially when for hours the thorax has been open, and experiments have been made on the greater vessels, or the functions of the heart, or on pericardial pressure, etc.… However, there can be no question that the manipulations of the heart, which are inseparable from our experiments, should be the cause of this result.” … (Here M. Cohnheim makes this naif remark), “Many observers have expressed surprise at the amount of pain which a dog’s heart can bear!”—“Ueber die Folgen der Krauzarterienver schliessung für das Herz,” Virchow’s Archiv., Vol. 85, 1881, pp. 520-21.
“The great majority of our experiments were made on dogs under curari with artificial respiration, but several were under morphia; with rabbits there is no particular difficulty in dispensing with all narcotics.”—Virchow’s Archiv.
Colasanti, Joseph. M.D. Univ. Rome.
Author of “Researches on Uric Acid,” Atti della R. Accademia di Roma, 1881; “Action of Oxygenated Water in Poisoning Dogs;” “Zur Kenntniss der Physiologischen Wirkungen des Curaregiftes,” Pflüger’s Archiv., Vol. XVI., pp. 157-8, &c.
Made experiments with curare at the Physiological Institute at Bonn. “… For these experiments we used middle-sized dogs, with well developed muscles and little fat. The method of preparing them for the desired experiments was as follows:—The dog was fastened on to the vivisection table. The abdomen was opened by a long cut in the linea alba from the sternum to the symphysis oss. pub.; to the right and left of the linea alba the muscles of the skin and abdomen were cut across and separated, so as to leave space for the preparation of the aorta abdominalis and the vena cava ascendens. Both these vessels were dissected out of their sheaths, and the threads required for binding the canula passed under the artery. While the animal bleeds to death a canula, which is intended to supply defibrinised blood, is fixed into the aorta.…”—“Zur Kenntniss der Physiologischen Wirkungen des Curaregiftes.”—Pflüger’s Archiv., Vol. XVI., pp. 157-8.
Colin, Gabriel Constant. B. at Mollars, Haute Saône, 1825. Prof. Veterinary College, Alfort. Mem. Acad. of Med., Paris.