Of the problems presented by the living body viewed as a machine, some may be spoken of as mechanical, others as physical, and yet others as chemical, while some are, apparently at least, none of these. In the seventeenth century William Harvey, laying hold of the central mechanism of the blood stream, opened up a path of inquiry which his own age and the century which followed trod with marked success. The knowledge of the mechanism of the animal and of the plant advanced apace, but the physical and chemical problems had yet to wait. The eighteenth century, it is true, had its physics and its chemistry; but, in relation at least to the problems of the living being, a chemistry which knew not oxygen and a physics which knew not the electricity of chemical action were of little avail. The philosopher of 1799, when he discussed the functions of the animal or of the plant involving chemical changes, was fain, for the most part, as were his predecessors in the century before, to have recourse to such vague terms as “fermentation” and the like; to-day our treatises on physiology are largely made up of precise and exact expositions of the play of physical agencies and chemical bodies in the living organisms. He made use of the words “vital force” or “vital principle,” not as an occasional, but as a common, explanation of the phenomena of the living body. During the present century, especially during its latter half, the idea embodied in those words has been driven away from one seat after another; if we use it now when we are dealing with the chemical and physical events of life, we use it with reluctance, as a deus ex machina to be appealed to only when everything else has failed.

Some of the problems—and those, perhaps, the chief problems—of the living body have to be solved, neither by physical nor by chemical methods, but by methods of their own. Such are the problems of the nervous system. In respect to these the men of 1799 were on the threshold of a pregnant discovery. During the latter part of this nineteenth century, especially during its last quarter, the analysis of the mysterious processes in the nervous system, and especially in the brain, which issue as feeling, thought, and the power to move, has been pushed forward with a success conspicuous in its practical, and full of promise in its theoretical, gains. That analysis may be briefly described as a following up of threads. We now know that what takes place along a tiny thread which we call a nerve fibre differs from that which takes place along its fellow threads, that differing nervous impulses travel along different nervous fibres, and that nervous and physical events are the outcome of the clashing of nervous impulses as they sweep along the closely woven web of living threads of which the brain is made. We have learned by experiment and by observation that the pattern of the web determines the play of the impulses, and we can already explain many of the obscure problems, not only of nervous disease, but of nervous life, by an analysis which is a tracking out of the devious and linked path of nervous threads. The very beginning of this analysis was unknown in 1799. Men knew that nerves were the agents of feeling and of the movements of muscles; they had learned much about what this part or that part of the brain could do; but they did not know that one nerve fibre differed from another in the very essence of its work. It was just about the end of the eighteenth century, or the beginning of the nineteenth, that an English surgeon began to ponder over a conception which, however, he did not make known until some years later, and which did not gain complete demonstration and full acceptance until still more years had passed away. It was in 1811, in a tiny pamphlet published privately, that Charles Bell put forth his New Idea, that the nervous system is constructed on the principle that “the nerves are not single nerves possessing various powers, but bundles of different nerves, whose filaments are united for the convenience of distribution, but which are distinct in office, as they are in origin, from the brain.”

Our present knowledge of the nervous system is to a large extent only an exemplification and expansion of Charles Bell’s New Idea, and has its origin in that.

If we pass from the problems of the living organism viewed as a machine to those presented by the varied features of the different creatures who have lived or who still live on the earth, we at once call to mind that the middle years of the nineteenth century mark an epoch in biologic thought such as never came before; for it was then that Charles Darwin gave to the world the “Origin of Species.”

That work, however, with all the far-reaching effects which it has had, could have had little or no effect, or, rather, could not have come into existence, had not the earlier half of the century been in travail preparing for its coming. For the germinal idea of Darwin appeals, as to witnesses, to the results of two lines of biologic investigation which were almost unknown to the men of the eighteenth century.

To one of these lines I have already referred. Darwin, as we know, appealed to the geological record; and we also know how that record, imperfect as it was then, and imperfect as it must always remain, has since his time yielded the most striking proofs of at least one part of his general conception. In 1799 there was, as we have seen, no geological record at all.

Of the other line I must say a few words.

To-day the merest beginner in biologic study, or even that exemplar of acquaintance without knowledge, the general reader, is aware that every living being, even man himself, begins its independent existence as a tiny ball, of which we can, even acknowledging to the full the limits of the optical analysis at our command, assert with confidence that in structure, using that word in its ordinary sense, it is in all cases absolutely simple. It is equally well known that the features of form which supply the characters of a grown-up living being, all the many and varied features of even the most complex organism, are reached as the goal of a road, at times a long road, of successive changes; that the life of every being, from the ovum to its full estate, is a series of shifting scenes, which come and go, sometimes changing abruptly, sometimes melting the one into the other, like dissolving views—all so ordained that often the final shape with which the creature seems to begin, or is said to begin, its life in the world is the outcome of many shapes, clothed with which it in turn has lived many lives before its seeming birth.

All, or nearly all, the exact knowledge of the labored way in which each living creature puts on its proper shape and structure is the heritage of the present century. Although the way in which the chick is moulded in the egg was not wholly unknown even to the ancients, and in later years had been told, first in the sixteenth century by Fabricius, then in the seventeenth century, in a more clear and striking manner, by the great Italian naturalist, Malpighi, the teaching thus offered had been neglected or misinterpreted. At the close of the eighteenth century the dominant view was that in the making of a creature out of the egg there was no putting on of wholly new parts, no epigenesis. It was taught that the entire creature lay hidden in the egg, hidden by reason of the very transparency of its substance; lay ready-made, but folded up, as it were; and that the process of development within the egg or within the womb was a mere unfolding, a simple evolution. Nor did men shrink from accepting the logical outcome of such a view—namely, that within the unborn creature itself lay in like manner, hidden and folded up, its offspring also, and within that, again, its offspring in turn, after the fashion of a cluster of ivory balls carved by Chinese hands, one within the other.

This was no fantastic view, put forward by an imaginative dreamer; it was seriously held by sober men, even by men like the illustrious Haller, in spite of their recognizing that, as the chick grew in the egg, some changes of form took place. Though so early as the middle of the eighteenth century Friedrich Casper Wolff, and, later on, others, had strenuously opposed such a view, it held its own, not only to the close of the century, but far on into the next. It was not until a quarter of the nineteenth century had been added to the past that Von Baer made known the results of researches which once and for all swept away the old view. He and others working after him made it clear that each individual puts on its final form and structure, not by an unfolding of preëxisting hidden features, but by the formation of new parts through the continued differentiation of a primitively simple material. It was also made clear that the successive changes which the embryo undergoes in its progress from the ovum to maturity are the expression of morphologic laws; that the progress is one from the general to the special; and that the shifting scenes of embryonic life are hints and tokens of lives lived by ancestors in times long past.