Alcohol and Acute Infections
In connection with experiments in rendering animals and men immune from certain contagious diseases through inoculation with specific serums, Deléarde, working in Calmette's laboratory in Lille, showed that alcoholized rabbits are not protected by inoculation, as normal ones are, against hydrophobia. Moreover, he reports the case of an intemperate man, bitten by a mad dog, who died notwithstanding anti-rabic treatment, whereas a boy of thirteen, much more severely bitten by the same dog on the same day, recovered under treatment. Deléarde strongly advises any one bitten by a mad dog to abstain from alcohol, not only during the anti-rabic treatment but for some months thereafter, lest the alcohol counteract the effects of the protective serum.
Similar laboratory experiments have been made by Laitenan, who became fully convinced that alcohol increases the susceptibility of animals to splenic fever, tuberculosis, and diphtheria. Dr. A. C. Abbott, of the University of Pennsylvania, made an elaborate series of experiments to test the susceptibility of rabbits to various micro-organisms causing pus-formation and blood poisoning. He found that the normal resistance of rabbits to infection from this source was in most cases "markedly diminished through the influence of alcohol when given daily to a stage of acute intoxication." "It is interesting to note," Dr. Abbott adds, "that the results of inoculation of the alcoholized rabbits with the erysipelas coccus correspond in a way with clinical observations on human beings addicted to the excessive use of alcohol when infected by this organism."
Additional confirmation of the deleterious effects of alcohol in this connection was furnished by the cats and dogs of Professor Hodge's experiments, already referred to. All of these showed peculiar susceptibility to infectious diseases, not only being attacked earlier than their normal companions, but also suffering more severely, This accords with numerous observations on the human subject; for example, with the claim made some years ago by McCleod and Milles that Europeans in Shanghai who used alcohol showed increased susceptibility to Asiatic cholera, and suffered from a more virulent type of the disease. Professor Woodhead points out that many of the foremost authorities now concede the justice of this view, and unreservedly condemn the giving of alcohol, even in medicinal doses, to patients suffering from cholera or from various other acute diseases and intoxications, including diphtheria, tetanus, snake-bite, and pneumonia, as being not merely useless but positively harmful. Even when the patient has advanced far toward recovery from an acute infectious disease, it is held still to be highly unwise to administer alcohol, since this may interfere with the beneficent action of the anti-toxins that have developed in the tissues of the body, and in virtue of which the disease has been overcome.
The Ally of Tuberculosis
Not many physicians, perhaps, will go so far as Dr. Muirhead of Edinburgh, who at one time claimed that he had scarcely known of a death in a case of pneumonia uncomplicated by alcoholism; but almost every physician will admit that he contemplates with increased solicitude every case of pneumonia thus complicated. Equally potent, seemingly, is alcohol in complicating that other ever-menacing lung disease, tuberculosis. Dr. Crothers long ago asserted that inebriety and tuberculosis are practically interconvertible conditions; a view that may be interpreted in the words of Dr. Dickinson's Baillie Lecture: "We may conclude, and that confidently, that alcohol promotes tubercle, not because it begets the bacilli, but because it impairs the tissues, and makes them ready to yield to the attacks of the parasites." Dr. Brouardel, at the Congress for the Study of Tuberculosis, in London, was equally emphatic as to the influence of alcohol in preparing the way for tuberculosis, and increasing its virulence; and this view has now become general—curiously reversing the popular impression, once held by the medical profession as well, that alcohol is antagonistic to consumption.
Corroborative evidence of the baleful alliance between alcohol and tuberculosis is furnished by the fact that in France the regions where tuberculosis is most prevalent correspond with those in which the consumption of alcohol is greatest. Where the average annual consumption was 12.5 litres per person, the death rate from consumption was found by Baudron to be 32.8 per thousand. Where alcoholic consumption rose to 35.4 litres, the death rate from consumption increased to 107.8 per thousand. Equally suggestive are facts put forward by Guttstadt in regard to the causes of death in the various callings in Prussia. He found that tuberculosis claimed 160 victims in every thousand deaths of persons over twenty-five years of age. But the number of deaths from this disease per thousand deaths among gymnasium teachers, physicians, and Protestant clergymen, for example, amounted respectively to 126, 113, and 76 only; whereas the numbers rose, for hotelkeepers, to 237, for brewers, to 344, and for waiters, to 556. No doubt several factors complicate the problem here, but one hazards little in suggesting that a difference of habit as to the use of alcohol was the chief determinant in running up the death rate due to tuberculosis from 76 per thousand at one end of the scale to 556 at the other.
Pneumonia and tuberculosis combined account for one-fifth of all deaths in the United States, year by year. In the light of what has just been shown, it would appear that alcohol here has a hand in the carrying off of other untold thousands with whose untimely demise its name is not officially associated. I may add that certain German authorities, including, for example, Dr. Liebe, present evidence—not as yet demonstrative—to show that cancer must also be added to the list of diseases to which alcohol predisposes the organism.
Hereditary Effects of Alcohol
If additional evidence of the all-pervading influence of alcohol is required, it may be found in the thought-compelling fact that the effects are not limited to the individual who imbibes the alcohol, but may be passed on to his descendants. The offspring of alcoholics show impaired vitality of the most deep-seated character. Sometimes this impaired vitality is manifested in the non-viability of the offspring; sometimes in deformity; very frequently in neuroses, which may take the severe forms of chorea, infantile convulsions, epilepsy, or idiocy. In examining into the history of 2554 idiotic, epileptic, hysterical, or weak-minded children in the institution at Bicêtre, France, Bourneville found that over 41 per cent. had alcoholic parents. In more than 9 per cent. of the cases, it was ascertained that one or both parents were under the influence of alcohol at the time of procreation,—a fact of positively terrifying significance, when we reflect how alcohol inflames the passions while subordinating the judgment and the ethical scruples by which these passions are normally held in check. Of similar import are the observations of Bezzola and of Hartmann that a large proportion of the idiots and the criminals in Switzerland were conceived during the season of the year when the customs of the country—"May-fests," etc.—lead to the disproportionate consumption of alcohol.