Of antiperistaltic globus in the œsophagus our author saw only two cases, which were not complicated with hysteria. The patients had both been subject to rheumatism; and, in one of them, this had been supplanted by an eruption Of tetter: on the disappearance of which last the globus appeared. These cases were cured, the latter by a severe, light diet, and some antispasmodics, the names of which are not mentioned; the other by curing the rheumatism.

Dissections are somewhat difficult to obtain; unless where some other more mortal disease exists. In one, scirrhus of the pylorus was found; the stomach greatly enlarged; the small intestines contracted, red outside and gray within. (Where was the redness situated; in the peritoneal or the muscular coat? We must guess the latter.) The stomach was pale gray, and thickened. The large intestines were dilated, and gray.—Journ. Univ.

21. Non-contagion of Yellow Fever.—Dr. Valentine, of Nancy, has printed a pamphlet of a single sheet, in which he finds himself involved in all the turmoil, through which American physicians passed during the period which intervened between 1793 and 1805. Dr. V. gives his authority decidedly in favour of the non-existence of a contagion in this disease; and grounds his opinion upon the innumerable cases of patients affected with the disease and otherwise, who have escaped from infected districts, without communicating the malady in any instance, to the persons with whom they lived; upon the healthiness of ports, from which it has been said to have been introduced, &c. Dr. V. is not, as some of his countrymen have been, unwilling, from some unimaginable cause, to make use of the immense mass of American evidence; though he observes, and with justice, that experiments should be repeated in France, in order to set the public mind at rest in that kingdom. He proposes the employment of criminals for this purpose; and recommends every mode of the most close contact which his imagination could suggest. He mentions experiments of this kind having been made in the United States; and by M. Guyon, of Martinique, on his own person.

He quotes Dr. Chervin's labours, with great and just applause. This indefatigable and daring physician has now spent upwards of ten years in accumulating proofs upon this single question.

At the commencement of the pamphlet, the arrangement of which does not seem to us to be quite clear and easy, Dr. V. gives a sketch of the situation and localities of Leghorn. He traces the fevers of that place to putrid matters, perceptible by the sense of smell; and principally to obstructed drains. He does not give the exact degree of heat, but merely states that it was excessive, and followed by heavy rains.

IV. THERAPEUTICS, MATERIA MEDICA, AND THE PRACTICE OF MEDICINE.

22. Iodine.—In the former numbers of this journal, we offered some observations respecting the medicinal properties of iodine, intending then to present in one of our future numbers an elaborate analysis of a valuable work on this subject, by Dr. Manson, which appeared in England sometime last year.[32] Fearing, however, that the want of room and time will prevent us from fulfilling this task, as soon as soon as might be desired, we have thought that a condensed notice of its contents would be acceptable in this place.

It appears that previously to the discovery of iodine as a medicinal agent, our author used the burnt sponge in bronchocele, a disease very common in the neighbourhood of Nottingham, where he practices. But when the effects of the former remedy was announced, Dr. M. prepared a tincture composed of one drachm of iodine to two ounces and a half of rectified spirit, (spec. grav. 916.) and prescribed it very extensively in doses of from 10 to 30 drops three times a day, according to the age and strength of the patient. Dr. Manson has presented a tabular view of 116 cases of bronchocele treated by iodine, and also a detailed account of 15 more cases, with appropriate remarks. Of the former, there were, viz:—

Males—Cured,10
Much relieved,1
Discharged for non-attendance,1
Improving under treatment,3—Total 15
Females—Cured,66
Much relieved,9
Not relieved,2
Discharged for non-attendance,10
Improving under treatment,14—101—116

Whilst using the tincture internally, Dr. Manson occasionally had recourse externally to a liniment composed of