Actions and Uses.—The manufacturers claim that it combines the laxative action of cascara with tonic properties of the bitter principle with the advantage of concealment of the disagreeable taste. Dosage.—One or two globules to be taken before retiring. Prepared by Parke, Davis & Co., Detroit, Mich.
CHINAPHENIN.
Chinaphenin, CO (NH·C6H4OC2H5) (C20H23N2O2) = C20H33N3O4, the quinine carbonic acid ester of phenetidin.
Actions and Uses.—Chinaphenin combines the antiperiodic properties of quinine with the analgesic power of phenacetin, with the advantage of tastelessness and asserted freedom from symptoms of cinchonism produced by the administration of the two remedies in simple mixture. It is recommended in febrile diseases, especially la grippe; in spasmodic conditions, such as whooping-cough; in certain forms of malaria and in neuralgia. Dosage.—Adult: 0·3 to 0·6 gramme (5 to 10 grains) ordinarily, 1·5 to 2 grammes (22 to 30 grains), given in two doses as an antipyretic in neuralgia and malaria; in whooping-cough: 0·13 to 0·3 gramme (2 to 5 grains), according to age. Manufactured by Farbenfabriken, vorm. Friedr. Bayer & Co., Elberfeld, Germany (Continental Color & Chemical Co., New York).
CHLORBUTANOL.
Chlorbutanol, 1,1,1-trichlor-2-methyl-propan-2-ol, CCl3·C (OH) (CH3)·CH3 = C4H7OCl3, produced by the reaction of acetone on chloroform.
Actions and Uses.—It is said to be absorbed unchanged, but to be decomposed in the body. It is a local anesthetic with an action weaker than that of cocaine, but sufficient to prevent vomiting from gastric irritation. Its antiseptic action is said to be fifteen times as strong as that of boric acid. It acts on the central nervous system similarly to chloral, and although the claim has been made that hypnotic doses are without effect on the circulation and respiration, independent observers have described a fall of blood pressure and interference with respiration in animals, and consider it fully as dangerous as chloral. In man 100 grains caused severe symptoms, but recovery occurred. It is claimed that no habit is induced, but this may be referable to its restricted employment. It is recommended as a mild local anesthetic, in dentistry, etc., as a preservative for hypodermic solutions, for insomnia, vomiting and for spasmodic conditions. It is also said to be useful as introductory to general anesthesia, lessening excitement and nausea. Dosage.—The dose is from 0·3 to 1·5 gramme (5 to 20 grains) dry or in capsules. Hypodermically as a local anesthetic a saturated aqueous solution may be used.
CHLORETONE.
A name applied to chlorbutanol, which see. Manufactured by Parke, Davis & Co., Detroit, Mich.