In 1840, the Third Baptist Church was organized. In 1846, the edifice, afterwards occupied by the Central Methodist Church, was built for this society. The pastors were the Reverend John G. Naylor, the Reverend Ira Person, the Reverend John Duncan, the Reverend Sereno Howe, the Reverend John Duer, and the Reverend John Hubbard. The church was disbanded in 1861.
The Worthen-street Methodist Episcopal Church was organized October 2, 1841, and the edifice was erected the following year. The succession of pastors has been the Reverend A.D. Sargent, the Reverend A.D. Merrill, the Rev. J.S. Springer, the Reverend Isaac A. Savage, the Reverend Charles Adams, the Reverend I.J.P. Collyer, the Reverend M.A. Howe, the Reverend J.W. Dadmun, the Reverend William H. Hatch, the Reverend A.D. Sargent, the Reverend L.R. Thayer, the Reverend William H. Hatch, the Reverend J.O. Peck, the Reverend George Whittaker. The present pastor is the Reverend Nicholas T. Whittaker.
The St. Peter's Roman Catholic Church was gathered on Christmas, 1841. The Reverend James Conway, the first pastor, was succeeded in March, 1847, by the Reverend Peter Crudden. The present rector is the Reverend M. Ronan, assisted by the Reverends John D. Colbert and Thomas F. McManus.
In 1843, the Lowell Missionary Society was established. The Reverend Horatio Wood officiated in the ministry and labored in free evening schools and Sunday mission schools, successfully.
The Kirk-street Congregational Church was organized in 1845; the edifice was built in 1846. The Reverend Amos Blanchard was installed the first pastor and continued to his death, January 14, 1870. He was succeeded by the Reverend C.D. Barrows. The present pastor is the Reverend Charles A. Dickinson.
The High-street Congregational Church was organized in 1846. Their edifice was built by the St. Luke's Episcopal Church, which was formed in 1842 and was disbanded, in 1844, under the ministration of the Reverend A.D. McCoy. The Reverend Timothy Atkinson was pastor from 1846 to 1847; the Reverend Joseph H. Towne, from 1848 to 1853; the Reverend O.T. Lanphier, from 1855 to 1856; the Reverend Owen Street, from September 17, 1857.
St. Mary's Roman Catholic Church was originally built for the Baptists, but was purchased in 1846 by the Reverend James T. McDermott, and consecrated March 7, 1847.