In conclusion, I would like to repeat the words of Prof. Neumann as to the differential diagnosis between meningitis, sinus thrombosis, and brain abscess: “A patient that has meningitis is one that wishes to be left alone and allowed to sleep, although when roused is not particularly irritable. If he has brain abscess then he is constantly very irritable and difficult to manage, while a patient that has sinus thrombosis when he is free from the chill and fever is very pleasant, apparently well.”
THE TREATMENT OF GONORRHEAL OPHTHALMIA
Arthur Edward Smith, M. D.
MINNEAPOLIS
In ophthalmology, as in other branches of medical science, the advance in therapeutics has hardly kept pace, in recent years, with that in pathology and diagnosis. Comparatively few of the therapeutic innovations of the past decade have stood the test of time; and, in the main, the ophthalmological materia medica of today bears a striking resemblance to that of fifteen or twenty years ago. Our poverty of therapeutic resource has been notably exemplified in the generally accepted method of treatment of gonorrheal ophthalmia; and the results obtained with the conventional treatment as outlined in the current text-books are far from satisfactory.
Gonorrheal ophthalmia, in both infants and adults, continues to cause an appalling amount of blindness; and only a part of this can, with justice, be ascribed to ignorance and neglect. The number of cases which, in spite of the most careful treatment, go on to corneal ulcer, perforation, panophthalmitis, and irreparable blindness, continues to be considerable. Further, a decided difference of opinion still exists among well-trained oculists of wide experience as to the best method of handling these cases. For over a hundred years silver nitrate has enjoyed an unquestioned pre-eminence in the treatment of the purulent ophthalmias, particularly those cases in which the gonococcus was the etiological factor; and even now to question its right to a place in the treatment of gonorrheal conjunctivitis seems to many to be as heretical as to abandon mercury in the treatment of syphilis. For many years the only difference of opinion in regard to silver nitrate seemed to be as to whether it should be employed in the first stage of the disease, or whether one should wait until the discharge became purulent. Of late years, however, a number of experienced oculists have gone on record as being of the opinion that the majority of these cases do distinctly better without the nitrate than with it. As is well known, the nitrate destroys only those gonococci lying upon the surface or in the most superficial layers of the conjunctiva; and, far from reaching those in the deeper layers, rather forms a film over the surface which protects them from the irrigating solution used later. It also appears to be certain that the use of the nitrate, for a time at least, increases the ratio of extra-to intracellular gonococci in the discharge, which furnishes another valid argument against its use. That a subsequent chronic conjunctivitis with hypertrophy is often a disagreeable sequel in cases in which an energetic course of silver nitrate has been used is a matter of common observation. The vogue of certain of the organic silver salts, such as argyrol, protargol, etc., is no doubt, not so much due to any intrinsic therapeutic merit which they possess as to the fact that the average case gets along better without the local application of strong chemical antiseptics. However one may feel about the abandoning of such a time-honored drug as the nitrate of silver in the treatment of this disease, it must be conceded that it is entirely inadequate to control the process in the severer cases, and as a therapeutic sheet-anchor leaves a great deal to be desired.
The use of cold compresses in gonorrheal ophthalmia continues to be advocated in text-books and practiced in many clinics, especially in America, in spite of the fact that the progressive men in general medicine and surgery seem pretty generally to have abandoned the use of cold applications in the treatment of acute inflammations of bacterial origin. Any merit the cold compresses may have in the reducing of the edema and relieving pain are more than counterbalanced by the fact that the vitality of the tissues is at the same time lowered. In cases in which there is a sufficient swelling of the lids to cause a dangerous pressure on the eyeball, cold should not for a moment be depended upon to control the inflammatory edema but instant recourse had to canthotomy: in cases where this swelling is not marked cold compresses are unnecessary and apart from a certain analgesic effect, of no value. The skepticism, which is becoming more general, in regard to the value of silver nitrate and cold applications has not extended to the third member of the classic trinity,—irrigations,—the efficacy of which seems to be generally conceded. Various substances have been advocated for this purpose,—boric acid, potassium permanganate, bichloride of mercury, normal salt solution, etc., and the consensus of opinion seems to be that it is practically indifferent which one of these is used, the action being mechanical rather than chemical. The ordinary method of half-hourly irrigations has been abandoned by Hosford, Ulbrich, and others in favor of the constant irrigation with the Hosford apparatus or some modification of it.
The English adherents of the constant irrigation treatment, who, for the most part, dispense with the use of silver nitrate altogether, report excellent results; but the method is not without its drawbacks. The apparatus is awkward to use, requires as much or more attention than the intermittent irrigations, and undoubtedly disturbs the rest of the patient at night more. Further, since the lids are, of course, not held apart for the constant irrigation, but the flow of the solution across the palpebral fissure is depended on to cleanse the eye of secretion, one is inclined to question whether the mechanical cleansing is as thorough as when the lids are gently held apart while the eye is being irrigated.
The more one sees of these cases, the more one is impressed with two things: first, that a certain percentage of them would make a complete and uncomplicated recovery, even if they were entirely untreated (undoubtedly this number is larger than we think, especially in children); second, that the usual treatment is entirely inadequate in those cases in which there is an especially virulent infection or a lowered resistance of the tissues. When antigonococcic serum was first developed and its action observed in cases of acute gonorrheal ophthalmia, the results were, as in acute urethritis, disappointing. Many oculists are of the opinion that the serum is entirely without value in acute blenorrhea, even though its use be indicated in metastatic eye disease of gonorrheal origin. Of late, however, at least two men in America have written enthusiastically of serum-therapy in acute gonorrheal conjunctivitis, advocating its employment in the usual manner and also its use locally, i.e., dropped into the conjunctival sac in place of the usual antiseptics. It would seem that the data now available hardly warrant a positive statement in regard to the serum-therapy.
The pathological findings in gonorrheal ophthalmia are simple but significant, in that the gonococcus of Neisser is found, not only on the surface and in the superficial cells of the conjunctiva, but also, often within forty-eight hours, has invaded the deeper layers of the epithelium and the subepithelial connective tissue. This at once makes clear the reason for the inefficacy of the local antiseptics, particularly those like silver nitrate, the action of which is very superficial. Organic silver preparations and irrigations of various kinds are equally powerless to reach any but the most superficially situated of the bacteria.
Since the destruction of the bacteria lying on the surface is not sufficient to control the disease, it may be stated that the problem of the destruction or inhibition of the deep-lying bacteria is the essential problem in curing gonorrheal ophthalmia.