It is evident from this description that the plague of 1720 was in nowise inferior to that of 1348. Fortunately, the disease did not spread beyond Provence. It is noteworthy that in many instances, in Marseilles, people secluded themselves in their houses, avoiding all communication with the outer world, and in this way escaped. Similar isolation of cloisters, insane asylums, likewise resulted in freedom from the disease which stalked so freely throughout the stricken city. It was experience of this kind in isolation of the healthy which led Defoe to write his ‘Due Preparations for the Plague.’

Toward the middle of the century the plague reasserted itself in the Danubian provinces, the constant battleground between the Turks and Russians and Austrians. In 1738 it not only prevailed in Russia but also invaded Hungary. Of more importance than this occurrence is the outbreak of the plague in 1743 in Sicily. The last epidemic of plague had occurred in Messina in 1624. After a lapse of one hundred and twenty years, it reappeared with terrible results. In Messina, as in Marseilles and in London, the first cases were not recognized as plague cases and, as a result, the infection spread until, like a veritable explosion, the disease developed all over the city. The plague, with its attendant misery of lack of food, and even of water, was in vain combated by religious processions. The plague corpses were in heaps in the streets, as in Marseilles, and cremation was resorted to in order to effect their removal. That year 30,000 died of plague in the city of Messina. With the exception of a slight epidemic at Noja in 1815, this outbreak in Messina in 1743 was the last one to appear in Italy.

In 1755, the plague was introduced into Transylvania by an Armenian merchant from the Black Sea. Before it was extinguished, 4,300 deaths were recorded.

Next to that of Marseilles and of Messina, the most noteworthy outbreak of plague was that which occurred in 1771 in Moscow. The disease was introduced by troops returning from the Danubian provinces. As so often has been the history of plague, the first cases were not recognized, and the existence of pest was denied. When the plague was demonstrated to be present, it is said by Haeser that three-fourths of the populace deserted the city. The disease began early in March and increased during the early summer months. In August over 7,000 deaths resulted, while in September the records show that 21,000 died. In October the plague decreased, but still 17,000 deaths attested to its fearful power. Early in January it became extinct, after a duration of ten months, and after having caused the death of more than 52,000 people.

Toward the close of the eighteenth century, at the time of the Napoleonic invasion of Egypt and Syria, the French armies came into contact with the plague. Bonaparte’s visit to the pest-stricken soldiers at Jaffa has been perpetuated in the historic canvas which is to be seen at Versailles.

During the nineteenth century the plague ravaged Northern Africa on diverse occasions. Constantinople was invaded in 1802, 1803, 1808. It was also present to a slight extent in the Caucasus and in Astrakhan. A notable plague epidemic appeared in Egypt in 1812, and soon spread through Turkey and Southern Russia. Constantinople and Odessa were severely scourged. In Odessa out of a population of 28,000 there died 12,000.

It is a noteworthy fact that the Napoleonic wars, with all their incident hardships and misery, did not develop or spread the plague in Europe. The outbreaks of the disease were limited during this period to Africa and to Turkey, Bosnia, Roumania, Dalmatia and to Southern Russia. Two exceptions, however, are to be noted. In 1812 the Island of Malta was infected and more than 6,000 of its people yielded to the disease. The epidemic of 1815 at Noja, in Apulia, was the first recurrence of the plague on Italian soil since 1743, and thus far it has been the last.

The Balkan Peninsula and Southern Russia were visited from time to time by the plague up to about 1841. For nearly forty years Europe was wholly free from the disease, which, however, continued its existence in Northern Africa, in Mesopotamia and in India. The Russo-Turkish war of 1878 brought the Russian troops into contact with the disease in the Caucasus, and the epidemic at Vetlianka on the lower Volga was unquestionably introduced by such returning soldiers.

Such, then, has been the history of the bubonic plague. No other epidemic disease can be traced authentically as far back as the ‘Black Death.’ The characteristic symptoms, the rapid death, the excessive mortality are all features which have been noted through more than twenty centuries. The plague bacillus discovered in 1894 by Yersin, judged by its effect, is neither more nor less virulent than its early progenitors. It has often died out in a given locality or country, it has even been forced back to its original ancestral home, but still the same type, the same species has perpetuated itself unchanged. If the plague on its present world-wide journey does not cause such terrible outbreaks as it has in the past, it will be not because the germ has been altered by time, but because man has changed in so far as he has slowly learned and profited by the lessons of previous epidemics.