2. Before operations in which greater areal bleeding is to be expected, it could be used to keep the operational region clear of interfering bleeding.
3. Persons having a long blood clotting time could benefit inestimably from such a remedy in cases of teeth extractions, etc.
4. In severe cases of lung or stomach hemorrhage which cannot be treated surgically at once, such a remedy could be life saving.
We believe we have such a remedy in “Polygal 10,” a preparation composed and tested in our institute, which does fulfill the above requirements. “Polygal 10” is a drug composed on a “pectin” base; its new method, differentiating it from other hemostats on a pectin base is to be found in the activation of pectin before composing it into the hemostat.
Before we tried the clinical use of the drug and had it probed, it was tested on human beings by thorough experiments as to its influence on the period of clotting and bleeding. The period of clotting was occasionally established in short intervals by 10 parallel definitions of free flowing venous blood according to the method of Buercker. The period of bleeding was measured by a stop watch after a wound at the ear had been inflicted by a “Frankeschen Schnepper.”
On the enclosed graphic chart (not reproduced) the curves of two experimental subjects are displayed (experimental subjects Nos. 200 and 207). The depth of decline and the duration of effect correspond to the average. It is to be mentioned with reference to the curves that various persons were always used for the experiments in order to avoid a possible accumulation of effect by the drug.
TRANSLATION OF DOCUMENT NO-656
PROSECUTION EXHIBIT 247