6. A discharge of flux, as of blood. Matt. ix. 20.

7. (Med.)

Defn: An artificial ulcer, usually made in the fleshy part of the arm or leg, to produce the secretion and discharge of pus for the relief of some affected part.

8. The final outcome or result; upshot; conclusion; event; hence,
contest; test; trial.
Come forth to view The issue of the exploit. Shak.
While it is hot, I 'll put it to the issue. Shak.

9. A point in debate or controversy on which the parties take affirmative and negative positions; a presentation of alternatives between which to choose or decide.

10. (Law)

Defn: In pleading, a single material point of law or fact depending in the suit, which, being affirmed on the one side and denied on the other, is presented for determination. See General issue, under General, and Feigned issue, under Feigned. Blount. Cowell. At issue, in controversy; disputed; opposing or contesting; hence, at variance; disagreeing; inconsistent. As much at issue with the summer day As if you brought a candle out of doors. Mrs. Browning. — Bank of issue, Collateral issue, etc. See under Bank, Collateral, etc. — Issue pea, a pea, or a similar round body, used to maintain irritation in a wound, and promote the secretion and discharge of pus. — To join, or take, issue, to take opposing sides in a matter in controversy.

ISSUE
Is"sue, v. i. [imp. & p. p. Issued; p. pr. & vb. n. Issuing.]

1. To pass or flow out; to run out, as from any inclosed place. From it issued forced drops of blood. Shak.

2. To go out; to rush out; to sally forth; as, troops issued from the town, and attacked the besiegers.