The fortunes of Cardenas varied considerably, but on the whole his extraordinary versatility kept him afloat in the public estimation. He at one time, however, very nearly incurred the popular resentment owing to his having taken up the body of a suicide, and caused it to be interred in holy ground from the force of a mere whim. The uproar consequent on this he managed to overrule, and having got the better of Don Gregorio, the Civil Governor, the Bishop actually elected himself Governor in his place, and now became supreme in Asuncion, from which place the Jesuits were forced to flee in haste to their establishments in the country.

Each side now brought endless charges against the other, and in the middle of the wordy warfare the validity of Cardenas's appointment to the Bishopric was questioned. Nevertheless, Cardenas succeeded in retaining his office, and after a while issued a declaration excommunicating the entire Order of the Jesuits, after which, having sworn to the people that he possessed a Decree from the King of Spain, he issued an order commanding the expulsion of the Jesuits from Paraguay. This was carried into effect at Asuncion, and the College of the Order was sacked and gutted by fire. Outside the boundaries of the capital, however, this command had no effect whatever, and the great settlements of the Jesuits far away in the forests were totally unaffected by any mandate given at Asuncion.

The Bishop had now gone too far in his policy of aggression. The High Court at Charcas summoned him to appear before its tribunal at once, and to give his reasons for the expulsion of the Jesuits and his appointment of himself as Governor of Paraguay. At the same time a new Governor, Don Sebastian de Leon, was appointed to Paraguay. Cardenas determined to resist. He raised an army, and, claiming Divine inspiration, promised his followers an undoubted victory, and ordered them to supply themselves with cords in order to bind the prisoners which should fall to their share. The rival forces met just outside Asuncion. The unfortunate troops of Cardenas found no use for their cords, since, totally defeated, they fled in haste. Judging mercy to be most seasonable at this juncture, the new Governor commanded his men to march to the capital, but to desist from pursuing the defeated forces.

In the meanwhile Cardenas had lost no time. Realizing his complete defeat, he had fled secretly to Asuncion. Arriving there ahead of Don Sebastian de Leon's forces, he had dressed himself in his finest robes and seated himself on the throne of the cathedral. It was there that Don Sebastian de Leon found him when he entered.

The new Governor acted with supreme courtesy; he kissed the Bishop's hand, and ceremoniously requested him to spare him the baton of the civil power. In silence Cardenas complied with his request, and then retired, accompanied by his retinue. After this Asuncion knew him no more. Naturally the days of his supreme power were over, but he was still provided with an ecclesiastical office. He was made Bishop of La Paz, a benefice he continued to hold until his death.

Owing largely to their situation, these provinces in the south-east of the Continent continued from time to time to elude some of the stricter regulations and restrictions which were supposed to be applied to the whole Continent. Thus at the end of the sixteenth century the Governorship of the River Plate was entrusted to Hernando Arias de Saavedra, who is more familiarly known as Hernandarias. He was the first colonial-born subject of Spain to be gratified by such an honour. The appointment, as a matter of fact, was somewhat remarkable, as without a doubt it was strictly against the spirit of the Laws of the Indies, which utterly forbade any appointment of the kind to be entrusted to a colonial-born person.

Hernandarias, it must be said, makes one of the most remarkable figures of all the high officials of the River Plate. He proved himself a strenuous warrior, and, anxious to extend his frontiers, he carried on a tremendous warfare with the fierce Indians of the Pampa. The Governor, moreover, was gifted with no little foresight and practical common sense. Finding it impossible to establish a footing among the implacable natives of Uruguay, he caused a number of cattle, horses, and sheep to be sent across the great river, and to be let loose among the rich pastures of that country. He knew, he said (and it was not long before the future proved him right), that this land would one day be the property of the Spaniards, and thus these cattle which he sent over would, when the time came, be found to have multiplied themselves to an infinite extent, which, of course, fell out as he had anticipated.

Hernandarias, moreover, led an expedition to the south, and endeavoured to take possession of Patagonia. Here, after various disasters, he inflicted a severe defeat on the Indians; but few definite steps towards the practical colonization of the far south appear to have been taken at this period.

Hernandarias, enthusiastic soldier though he proved himself, by no means confined his energies to the arts of war; in statesmanship his ideas were progressive. Having once subdued the wilder Indians, he led the way to peaceful co-operation. According to Señor J.M. Estrada—

"Hernandarias devoted his whole soul to the development of a species of colonization which he terms the spiritual conquest—that is to say, he inculcated into the country the Christian spirit of discipline, civilization, and concord. He awoke the soul of the savage, and turned his instincts in search of better things than he had known. He closed the barracks of the soldiers and opened the Colleges of the Missionaries."