The great palace called Somerset House was at first built by the Protector Somerset, brother of Jane Seymour. He cleared away to make room for it the palace of the Bishops of Worcester and Chester, the Strand Inn belonging to the Temple, and many other buildings. The cloister on the north side of St. Paul's containing the "Dance of Death" was demolished in order to find stones for the new building, which was unfinished when the Protector was beheaded in 1552. The architect is supposed to have been John of Padua. It is not, however, certain how far the place was completed at the death of the Protector. Elizabeth gave the keeping of the house to her kinsman, Lord Hunsdon. James called it Denmark House. Charles gave it to his Queen, Henrietta Maria, and built a chapel for the Roman Catholic service. Some of the Queen's attendants are buried here; their tombs are in vaults under the great square. A register of the marriages, baptisms and burials which have taken place at Somerset House has been published by Sir T. Philips. Here Henrietta appeared in a masque; here died Inigo Jones; here Oliver Cromwell's body lay in state; after the Restoration Henrietta returned here for a time; Catherine of Braganza succeeded; here the body of Monk, Duke of Albemarle, lay in state; and here, after Catherine left England, the place became like the Savoy, the favoured residence of the poorer nobility. The old building was destroyed in 1775.

In the new Somerset House, erected 1776-1786—architect, Sir William Chambers—were for many years held the meetings of the Royal Society; the Society of Antiquaries; the Royal Academy of Arts; the Astronomical, Geological and Geographical Societies. A great deal of public business is carried on at Somerset House. The east wing is occupied by King's College, founded in 1828. Opposite to Somerset House a stream came down from the higher ground; it was crossed by the Strand Bridge. The waters flowed through the palace into the river.

On the east side of Somerset House stood Arundel House, originally Bath's Inn, as the town-house of the Bishop of Bath and Wells. In this house were set up the famous Arundel marbles. The Duc de Sully, who was lodged here during his embassy to England on the accession of James I., speaks of it as a most commodious house. Near Arundel House and Somerset House was an Inn of Chancery called Chester Inn.

Among the buildings destroyed to make room for Somerset House was a small church dedicated to the Virgin Mary, and, according to some, to St. Ursula. The Duke of Somerset promised to build another for the people, but was beheaded before he could fulfil his promise. On the present site of St. Mary's Church, and at the west end, stood a stone cross where the justices itinerant sat at certain seasons, and also on the site was the old Strand well. The cross became decayed, and a maypole was erected either on its site or close beside it. The Puritans pulled down the maypole, but after the Restoration another and a much taller one, measuring in two pieces 134 feet, was put up by sailors under the direction of the Duke of York amid the rejoicings of the people. The maypole stood until 1713, when the remaining portion was carried away to Wanstead Park, where it was used for holding a telescope. The Church of St. Mary le Strand was built 1714-1723 by James Gibbs. It was the first of the fifty new churches ordered (not all built) by Queen Anne, and it was at first called New Church. The style of the church has been vehemently abused, and yet it has grown in favour and has now many admirers. It is divided into two parts, of which the lower has no window, being built solid to keep out the noise of the street. The windows are in the upper part. The church within is nobly ornamented and is without galleries. Before the west end of the church was the first stand for hackney coaches.

"Around that area side they take their stand,
Where the tall maypole o'erlooked the Strand;
And now—so Anne and Piety ordain—
A church collects the saints of Drury Lane."

And again the poet asks:

"What's not destroyed by Time's devouring hand?
Where's Troy—and where's the Maypole in the Strand?"

Mrs. Inchbald lived by the side of the New Church in the Strand.

The immense changes taking place in the Strand begin to be very noticeable opposite Somerset House. At the time of writing a few houses at the corner of Wellington Street are still standing, but will soon disappear.

On the south side of the Strand, just beyond the east end of St. Mary's Church, is a narrow entry called Strand Lane. This was formerly Strand Bridge, over one of the rivulets running down to the Thames, and later it still retained the same name, meaning the bridge or landing stairs at the river end.