Soon after his return to England Park married the daughter of Mr Anderson, with whom he had served his apprenticeship, and resided a couple of years with his mother and one of his brothers on the farm that his father had occupied at Fowlshiels, in Scotland. After this he practised his profession for some time at Peebles. But this sort of life not satisfying his ardent temperament, on hearing from Sir Joseph Banks that another expedition into Africa to explore the Niger was proposed, he at once offered his services.

Nothing, however, was settled till the year 1803, when, being directed to hold himself in readiness to proceed to Africa, he engaged a native of Mogadore, named Sidi Omback Boubi, then residing in London, to accompany him to Scotland for the purpose of instructing him in Arabic.

Nearly another year passed before all arrangements were concluded. It was finally determined that the expedition should consist of Park himself, his brother-in-law (Mr Anderson), and Mr George Scott, who was to act as draughtsman, together with a few boat-builders and artificers. They were to be joined at Goree by a party of soldiers of the African corps stationed in that garrison.

Three months after this elapsed ere they set sail on board the “Crescent” transport on the 30th of January, 1805; and, after touching at Saint Jago to obtain asses for the journey, they reached Goree on the 28th of March.

There was no lack of volunteers, the whole garrison offering their services. Thirty-five soldiers under the command of Lieutenant Martyn of the Royal Artillery Corps were selected, as well as two sailors from the “Squirrel” frigate.

They left Goree on the 6th of April, the men jumping into the boats in the highest spirits, and bidding adieu to their friends with repeated huzzas.

Landing at Kayee on the northern bank of the Gambia, they commenced their overland journey to Pisania on the 27th of April. The weather was intensely hot, and the asses, unaccustomed to carry loads, made their march very fatiguing and troublesome, three of the animals sticking fast in a muddy rice field soon after they started.

So many delays had occurred that the rainy season was already approaching, and it would have been more prudent had the expedition remained at Goree or Pisania till the country had become again suitable for travelling. It was just possible, however, that they might reach the Niger before the middle of June, when the rainy season usually commences, and that river could then have been navigated without much exposure or toil. So eager, however, was Mr Park to proceed, that he disregarded the warnings of his friends, and determined to set forth on his journey.

Several days were lost at Pisania in arranging the burdens of the asses and in purchasing more animals, as those they possessed were not sufficient for carrying all the loads.

He here engaged a Mandingo priest named Isaaco, who was also a travelling merchant, to serve as a guide, and, on the 4th of May, all being ready, the caravan set forth from Pisania, whence nearly ten years before Park had commenced his adventurous journey into the interior.