I live near the University, and attend all the lectures on physiology that are given there, but am unable to do anything in the Laboratory, or to attend the cliniques or Virchow's lectures and demonstrations, etc. Du Bois-Raymond, an irascible man of about forty-five, gives a very good and clear, yea, brilliant, series of five lectures a week, and two ambitious young Jews give six more between them which are almost as instructive. The opportunities for study here are superb, it seems to me. Whatever they may be in Paris, they cannot be better. The physiological laboratory, with its endless array of machinery, frogs, dogs, etc., etc., almost "bursts my gizzard," when I go by it, with vexation. The German language is not child's play. I have lately begun to understand almost everything I hear said around me; but I still speak "with a slight foreign accent," as you may suppose—and, with all my practice in reading, do not think I can read more than half as fast as in English. It is very discouraging to get over so little ground. But a steady boring away is bound to fetch it, I suppose; and it seems to me it is worth the trouble.

The general level of thoroughness and exactness in scientific work here is beyond praise; and the abundance of books on every division of every subject something we English have no idea of. It all comes from the thorough mode of educating the people from childhood up. The Staats Examina, before passing which no doctor can practise here in Prussia, exact an amount of physiological, and what we at home call "merely theoretical" knowledge of the candidate, which a young doctor at home would claim and receive especial distinction for having made himself master of. But the men here think it but fair; gird about their loins and set about working their way through. The general impression the Germans make on me is not at all that of a remarkably intellectually gifted people; and if they are not so, their eminence must come solely from their habits of conscientious and plodding work. It may be that their expressionless faces do their minds injustice. I don't know enough of them to decide. But I know the work is a large factor in the result. It makes one repine at the way he has been brought up, to come here. Unhappily most of us come too late to profit by what we see. Bad habits are formed, and life hurries us on too much to stop and drill. But it seems to me that the fact of so many American students being here of late years (they outnumber greatly all other foreign students) ought to have a good influence on the training of the succeeding generation with us. Tuck, Dwight, Dick Derby, Quincy, Townsend, and Heaven knows how many more are in Vienna. Tuck and Dwight write me that they are getting on remarkably well. I saw them both here in September and think T. D. improves a good deal as he grows older.

Berlin is a bleak and unfriendly place. The inhabitants are rude and graceless, but must conceal a solid worth beneath it. I only know seven of them, and they are of the élite. It is very hard getting acquainted with them, as you have to make all the advances yourself; and your antagonist shifts so between friendliness and a drill sergeant's formal politeness that you never know exactly on what footing you stand with him. These Prussians bow in the most amusing way you ever saw,—as if an invisible hand suddenly punched them in the abdomen and an equally invisible foot forthwith kicked them in the rear,—one time and two motions, and they do it 100 times a day.

But enough of national gossip—let us return to that about individuals. Oh! that I could see thy prominent nose and thy sagacious eyes at this moment relieved against the back of that empty arm-chair that stands opposite this table. Oh! that we might once again sit apart from the fretful and insipid herd of our congeners, and take counsel together concerning the world and life—our lives in particular, and all life in general. How the shy goddess would tremble in her hiding-places at the sound of our unerringly approaching voices. And how you would pour into my astonished ear all that is new and wonderful about pathology and microscopical research, all that is sound and neat about operative surgery, while I would recite the most thrilling chapters of Kolliker's "Entwickelungs-geschichte," or Helmholtz's "Innervationsfortpflanzungsgeschwindigkeitsbestimmungen"! I suppose you have been rolling on like a great growing snowball through the vast fields of medical knowledge and are fairly out of the long tunnel of low spirits that leads there by this time. It is only three months since I have taken up medical reading, as I made all sorts of excursions into the language when I came here, and, owing to the slowness of progression I spoke of above, I have not got over much ground. Of course I can never hope to practise; but I shall graduate on my return, and perhaps pick up a precarious and needy living by doing work for medical periodicals or something of that kind—though I hate writing as I do the foul fiend. But I don't want to break off connexion with biological science. I can't be a teacher of physiology, pathology, or anatomy; for I can't do laboratory work, much less microscopical or anatomical. I may get better, but hardly before it will be too late for me to begin school again.

I'll tell you what let's do! Set up a partnership, you to run around and attend to the patients while I will stay at home and, reading everything imaginable in English, German, and French, distil it in a concentrated form into your mind. This division of labor will give the firm an immense advantage over all of our wooden-headed contemporaries. For, in your person, it will have more experience than any one else has time to acquire; and in mine, more learning. We will divide the profits equally, of course; and he who survives the other (you, probably) will inherit the whole. Does not the idea tempt you? If you don't like it, I'll go you halves in the profits in any other feasible way. Seriously, you see I have no very definite plans for the future; but I have enough to keep body and soul together for some years to come, and I see no need of providing for more. This talk of course is only for your "private ear." I want you to write immediately on receipt of this,—for if you don't then, you never will,—and tell me all about what you've been doing and learning and what your future plans are. Also, gossip about the School and Hospital. I have not had a chance to talk medicine with any one but Dwight and Tuck (for a week), and hunger thereafter.... Believe me, ever til deth, your friend

WM. JAMES.

T. S. Perry of '66, who lives with me here, reminds me of a story to tell you. He lived with Architect Ware in Paris, and Ware received a visit from Dr. Bowditch and Mr. Dixwell last summer. The concierge woman was terribly impressed by the personal majesty of your uncles, particularly of Dr. Bowditch, of whom she said: "Il a le grand air, tout à fait comme Christophe Colomb!" It would be curious to understand exactly who and what she thought C. C. was, or whether she would have thought Mr. Dixwell like Americus Vespucius if she had known him.

To O. W. Holmes, Jr.

BERLIN, Jan. 3, 1868.

My dear Wendle,—Ich weiss nicht was soll es bedeuten, dass ich so traurig bin, tonight. The ghosts of the past all start from their unquiet graves and keep dancing a senseless whirligig around me so that, after trying in vain to read three books, to sleep, or to think, I clutch the pen and ink and resolve to work off the fit by a few lines to one of the most obtrusive ghosts of all—namely the tall and lank one of Charles Street. Good golly! how I would prefer to have about twenty-four hours talk with you up in that whitely lit-up room—without the sun rising or the firmament revolving so as to put the gas out, without sleep, food, clothing or shelter except your whiskey bottle, of which, or the like of which, I have not partaken since I have been in these longitudes! I should like to have you opposite me in any mood, whether the facetiously excursive, the metaphysically discursive, the personally confidential, or the jadedly cursive and argumentative—so that the oyster-shells which enclose my being might slowly turn open on their rigid hinges under the radiation, and the critter within loll out his dried-up gills into the circumfused ichor of life, till they grew so fat as not to know themselves again. I feel as if a talk with you of any kind could not fail to set me on my legs again for three weeks at least. I have been chewing on two or three dried-up old cuds of ideas I brought from America with me, till they have disappeared, and the nudity of the Kosmos has got beyond anything I have as yet experienced. I have not succeeded in finding any companion yet, and I feel the want of some outward stimulus to my Soul. There is a man named Grimm here whom my soul loves, but in the way Emerson speaks of, i.e. like those people we meet on staircases, etc., and who always ignore our feelings towards them. I don't think we shall ever be able to establish a straight line of communication between us.