Physiological effects on the eye.—L. ii./84,911.

Seven eye cases under its influence.—Med. Rec. (N. Y.) 1884,510.

Use in the nasal cavity, cotton wool soaked in 2 per cent. solution applied at the end of a probe in over forty cases, including hypertrophy of the nasal mucous membrane (twenty-seven cases cauterized), acute coryza, nasal polypus and hay-fever, all having marked swelling of the nasal mucous membrane, both from chronic and acute causes; in every case there was complete subsidence of the turgescence of the membrane and the sinuses were emptied of their blood.—Med. Rec. (N.Y.) 1884,533.

Cocaine solution applied to a blistered surface anæsthetizes the part.—B.M.J. i./85,300.

Solution painted on or injected into piles relieves the pain of operating on them.—B.M.J. i./85,227.

References to its surgical use as a local anæsthetic:—L. ii./84,608 (ophthalmic), 683 (ophthalmic), 936 (laryngeal), 975 (ophthalmic), 975 (nasal), 992 (ophthalmic), 1022 (physiological action), 1023 (ophthalmic and aural), 1068 (ophthalmic), 1097 (ophthalmic), 1123 (ophthalmic and dental), 1167 (circumcision and catheter passing); L. i./85,86 (uterine, vaginal, and oral), 123 (in tenesmus), 130 (on mucous membranes), 168 (dental), 220 (rectal), 226,315 (minor surgery), 965 (ophthalmic), 1033 (fistulas, canals), 1067 (ophthalmic), 1097 (nasal), 1112 (ophthalmic); B.M.J. ii/84,761 (ophthalmic), 1074 (laryngeal), 1132, 1142,1143,1249,1256 (ophthalmic), 1133 (dysphagia), 1188 (throat and nose), 1255 (laryngoscopic), 1256 (midwifery and tinnitus); B.M.J. i./85,45,77,134,145,863 (effects on the eye); B.M.J. i./85,24,36,77,235,286,456,792,1266 (ophthalmic surgery); B.M.J. i./85,36,47,209,456,479 (nose and larynx); B.M.J. i./85,377 (cancer); B.M.J. i./85,227,653,994 (rectal operations); B.M.J. i./85,17,36,47,361,994 (vagina and urethra); B.M.J. i./85,17,24,36,69,736,926 (in dentistry); B.M.J. i./85,402 (for scalds); B.M.J. ii./85,396 (tumour of lip removed); B.M.J. ii./85,1060 (removal of ingrowing toe-nail); L. ii./85,829; Th. Gaz., June, 1890, 415 (preceding iodine injection in hydrocele); B.M.J. ii./86,413 (dilatation of urethra); B.M.J. ii./88,491; i./8,1113 (minor surgery); B.M.J. i./89,943 (circumcision).

Translation of Carl Koller’s report of the earliest observations on the use of cocaine and its salts as local anæsthetics.—L. ii./84,990.

Hydrochlorate of cocaine, 20 per cent. solution allowed nitric acid to be applied to the tongue without pain.—L. ii./84,1023.

In skin diseases, relieves the inflammation in eczema and acne and the irritation of urticaria.—L. i. 85,76.

Fungoid growths in aqueous solutions of salts of cocaine and other alkaloids.—L. i./80,224,315,504,597,647.