November 12: 10 a. m., 8 cc urine collected, reduction heavy, only a few cubic centimeters obtained from bladder, did not contain any sugar, general condition of rabbit good, no symptom of caffein intoxication.
Rabbit 321. Yellow, female. Weight, 1,135 grams. Diet, oats.
March 16, 1910: 11.50 a. m., 14 cc 2 per cent caffein (246 mg per kilo) injected subcutaneously in the back; 2 p. m., reflexes increased, is very sensitive, started to run when put on floor, no handling except what was required for removal and return to cage, feces soft.
March 17: 9.30 a. m., condition good, rabbit put on floor, gait normal, but does not care to walk.
March 18: 9 a. m., walks around when put on floor, appetite good, condition seems to be normal.
March 25: 11 a. m., rabbit still alive, condition good.
Rabbit 250. Belgian hare, female. Weight, 1,435 grams. Diet, oats at least two days before the experiment.
November 11: 11 a. m., urine obtained from bladder acid to litmus, no albumin, no sugar; 11.10 a. m., 18 cc, 2 per cent caffein (252 mg per kilo); 3.45 p. m., reflexes and hyperæsthesia, no tetanus; 4 p. m., 60 cc urine, marked reduction of Fehling's solution.
November 12: 10 a. m., condition of rabbit good, no symptoms of caffein intoxication, 80 cc urine collected, sugar considerable, only a few cubic centimeters of urine obtained from bladder, no reduction of Fehling's solution.