Rabbit 395. Belgian hare, male. Weight, 1,410 grams.
August 18: 1 p. m., 20 cc 2 per cent caffein (283 mg per kilo) injected subcutaneously in the back; 4 p. m., reflexes markedly increased; 5 p. m., reflexes about the same, but no tetanus.
August 19, 9.15 a. m.: Reflexes increased markedly.
August 21, weight, 1,215 grams. Given 275 mg per kilo of caffein; no symptoms observed.
August 23, found dead. Autopsy: Liver greatly engorged; stomach fairly well distended and mucous membrane in a slightly inflammatory condition; contents of small intestine liquid in nature, but walls of same appeared normal; other organs normal in appearance.
Rabbit 396. Belgian hare, female. Weight, 1,475 grams. Diet, oats.
August 18: 1 p. m., 20 cc 2 per cent caffein (272 mg per kilo) injected subcutaneously in the back; 4 p. m., reflexes increased markedly; 5 p. m., reflexes increased markedly but no tetanus.
August 19: 10.30 a. m., reflexes still increased very markedly; rabbit jumps when touched.
August 21: Weight, 1,245 grams. Injected subcutaneously 275 mg of caffein per kilo; reflexes increased, posterior extremities stiff over hour later.
August 22: 9 a. m., found dead. Autopsy: Thoracic organs normal in appearance; stomach distended and mucous membrane affected with a catarrhal inflammation; contents of stomach were covered with a shiny mucus; contents of small intestine liquid in nature and bile stained; liver showed a coccidial infestation; kidneys and spleen normal in appearance.