June 3: 10 a. m. 21 cc of 2 per cent caffein (0.3 gram per kilo) injected subcutaneously; 12 noon, found dead.
Although there was considerable difference in the duration of life following the injection of the same dose of caffein per kilo, the final outcome was the same, as both cats died from the effects of the drug. One died within 2 hours and the other lived more than 30 hours after its administration. Three decigrams of caffein per kilo is, therefore, surely fatal to these animals. Tests made with smaller doses are shown in the following experiments:
Series B.
In these experiments the doses employed ranged between 0.20 and 0.25 gram caffein per kilo.
Cat 3. Black and white female. Weight, 2,854 grams. Well fed.
June 4: 10.30 a. m., 35 cc 2 per cent caffein (0.25 gram per kilo) injected subcutaneously; 11 a. m., found dead.
Cat 6. Black and white. Weight, 1,645 grams.
June 3: 20 cc 2 per cent caffein (0.243 gram per kilo) injected subcutaneously at 3 p. m., cat grew very irritable in a few minutes; about 4 p. m. reflexes decidedly increased; 5 p. m., cat paralyzed.
June 4: Cat found dead.