While. Avoid the indiscriminate use of this word for and, but, and although. Many writers use it frequently as a substitute for and or but, either from a mere desire to vary the connective, or from uncertainty which of the two connectives is the more appropriate. In this use it is best replaced by a semicolon.

The office and salesrooms are on the ground floor, while the rest of the building is devoted to manufacturing.The office and salesrooms are on the ground floor; the rest of the building is devoted to manufacturing.

Its use as a virtual equivalent of although is allowable in sentences where this leads to no ambiguity or absurdity.

While I admire his energy, I wish it were employed in a better cause.

This is entirely correct, as shown by the paraphrase,

I admire his energy; at the same time I wish it were employed in a better cause.

Compare:

While the temperature reaches 90 or 95 degrees in the daytime, the nights are often chilly.Although the temperature reaches 90 or 95 degrees in the daytime, the nights are often chilly.

The paraphrase,

The temperature reaches 90 or 95 degrees in the daytime; at the same time the nights are often chilly,