And several children and adults were inoculated from the arm of Pead on 5th April. “The greater part of them sickened on the sixth day, and were well on the seventh; but in three of the number a secondary indisposition arose in consequence of an extensive erysipelatous inflammation which appeared on the inoculated arms. By the application of mercurial ointment to the inflamed parts (a treatment recommended under similar circumstances in the inoculated Smallpox) the complaint subsided without giving much trouble.”
Excell was inoculated in three places on her arm. “This,” said Jenner, “was not done intentionally, but from the accidental touch of the lancet, one puncture being always sufficient.” The resulting pustules so much resembled those arising from inoculation with Smallpox, “that an experienced inoculator would scarcely have discovered a shade of difference.”
XXII.—Four Children.
On 12th April virus was taken from Hannah Excell and inserted in the arms of—
| Robert F. Jenner, | aged 11 months, |
| John Marklove, | ” 18 ” |
| Mary Pead, | ” 5 years, |
| Mary James, | ” 6 ” |
R. F. Jenner did not “take.” The arms of the others inflamed, and Jenner fearing erysipelas, as in the preceding cases, applied a caustic of soap and quick-lime to Marklove and James, “which,” he says, “effectually answered my intention in preventing erysipelas.” The disease was suffered to take its course in Pead, and no erysipelas appeared.
XXIII.—John Barge, aged seven.
Inoculated from Mary Pead, and successfully. Was subsequently inoculated with Smallpox without effect.
“These experiments,” said Jenner, “afforded me much satisfaction; they proved that the matter in passing from one human subject to another, through five gradations, lost none of its original properties, John Barge being the fifth who received the infection successively from Wm. Summers, the boy to whom it was communicated from the Cow.”