Physiological Researches on Life and Death

by Xavier Bichat

2dly, Experiments made in the same manner upon the spinal marrow of the neck, present the same results.

3dly, If the eighth pair of nerves be irritated, the movements of the heart will not be accelerated; they will not be arrested if these two nerves be divided. In all these experiments, however, we must be careful to make a proper distinction between the emotions and passions of the animal, and what it really suffers from the experiment.

4thly, The nature of the great sympathetic nerve, I suppose to be known;[114] now if the same experiments be made on the cardiac branches of this nerve, as were made upon the eighth pair, the same results will follow.

I do not offer in detail the whole of these experiments; the greater part of them are well known: I was induced to repeat them, as authors are not agreed upon their consequences.

The experiments of galvanism, are well calculated to throw light upon the relations existing between the heart and the brain; these I have taken care to repeat with the utmost exactness, and whatever authors may have advanced, they are all in favour of the above opinions—for 1st, If the galvanic apparatus be applied to the brain, and to the heart, and inferior extremities of a frog, and the communication made between the metals, there will constantly be seen a strong contraction in the muscles of the limb, and little or none in the heart. The same will be the case, to whatever voluntary muscle the zinc be applied. 2dly, The same results will be had, on the communication being made between the metals applied on the one hand to the spinal marrow above the giving off of the sympathetic, and on the other hand to the heart, and any of the voluntary muscles.

3dly, On establishing a communication between the metals applied to the cardiac nerves, and to the heart of the animal, there has been no contraction in the heart. In all these essays, the natural disposition between the parts which serve to unite the two organs, is preserved: there are other experiments which consist in detaching the heart from the breast. 2dly, In placing two points of its surface in contact with two different metals. 3dly, In making the communication between them with a third. From this experiment, Humboldt and other philosophers have procured contractions, but I have taken care to repeat it with the greatest accuracy, and must assert, that I have seen little or nothing of the kind; indeed, if I had, I should have concluded nothing from it; for it appears to me, that to decide upon the influence of the brain over the heart, a portion at least of the nervous system, should be in contact with one of the metals.

I shall now pass to my experiments on red and warm-blooded animals. They are necessary for the decision of the question before us, as the mode of contractility in these animals differs much from that of the animals submitted to the experiments already mentioned.

1st, In the winter of the year 1798, I was authorized to make different essays on the bodies of persons who had been guillotined. I had them at my disposal thirty or forty minutes after they had undergone the punishment. In some of them, all mobility was extinct; in others, this property could be reanimated in all the muscles by the common agents, and in those of the animal life, by galvanism especially.[115] Notwithstanding which, I could never occasion the least motion, in applying the apparatus either to the spinal marrow and the heart, or to this latter organ and the nerves, which it receives from the ganglions of the sympathetic, or the par vagum. Nevertheless, the common mechanical excitant, immediately applied to the fleshy fibre, occasioned its contraction. Could this have happened in consequence of the separation of the nervous fillets from the brain? assuredly not; because the voluntary muscles were equally separated from it, and yet affected strongly. If any doubt remain, the following experiments will clear it up.

2dly, In dogs and guinea pigs, I have repeatedly applied the metals, first to the brain and the heart, then to the trunk of the spinal marrow, and the heart; then to the par vagum and the heart. The communication being made, was followed by no apparent result.