Synthesis of 2-methyl-4-selenoquinazolone, 2-phenylbenzoselenazole, and its derivatives / Dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Faculty of Pure Science of Columbia University

by Yü-Gwan Chen

Selenocarbamide and a number of its derivatives have been prepared and studied. One class of seleno ureas has been patented as pharmaceutical products by Chem. Fabrik von Heyden[(24)], and are prepared by the action of hydrogen selenide on alkylcyanamides,

RNH.CHN + H₂Se = RNH.CSe.NH₂

They possess pronounced therapeutic value and, serve as intermediate products in the production of more stable alkyl halide additive compounds. Other carbamides ranging from seleno urea itself[(25)], (III) and a cyclic urea[(26)] (IV) are described in the literature:

The latter, known as ethylene-selenourea, may be classified also in the azole group as 2-iminotetrahydroselenazole (V).

The literature for the other normal carbamides is listed in the bibliography[(27)].

Selenoantipyrines, selenosaccharine, selenoindigoes have also been prepared.