Sir:

In consequence of the receipt of the inclosed letters, I have thought proper to send you an express, to enable you to announce to the Osage the designs of their enemies, that they may take seasonable measures to circumvent them. You will not fail, in addition to the within talk, to enhance our paternal regard for this nation by every proper expression; but are to keep clear of any conflict in which they may be involved, though you are to avoid the appearance of abandoning them. If it should be the Potowatomies' intention to carry their threat into execution, it is probable they will not attempt to make the blow before the falling of the leaves; and in the mean time the Osages should establish a chain of light scouts along the coast of the Missouri, to ascertain with certainty the approach of their enemy.

It is reduced to a certainty that [Manuel de Lisa] and a society of which he is the ostensible leader have determined on a project to open some commercial intercourse with Santa Fe; and as this may lead to a connection injurious to the United States, and will, I understand, be attempted without the sanction of law or the permission of the executive, you must do what you can consistently to defeat the plan. No good can be derived to the United States from such a project, because the prosecution of it will depend entirely on the Spaniards, and they will not permit it, unless to serve their political as well as their personal interests. I am informed that the ensuing autumn and winter will be employed in reconnoitering and opening a connection with the Tetaus, Panis, etc.; that this fall or the next winter, a grand magazine is to be established at the Osage towns, where these operations will commence; that [Lisa] is to be the active agent, having formed a connection with the Tetaus. This will carry forward their merchandise within three or four days' travel of the Spanish settlements, where they will deposit it under a guard of 300 Tetaus. [Lisa] will then go forward with four or five attendants, taking with him some jewelry and fine goods. With those he will visit the governor, to whom he will make presents, and implore his pity by a fine tale of sufferings which have been endured by the change of government; that they are left here, with goods to be sure, but not a dollar's worth of bullion, and therefore they have adventured to see him, for the purpose of praying his leave for the introduction of their property into the province. If he assents, then the whole of the goods will be carried forward; if he refuses, then [Lisa] will invite some of his countrymen to accompany him to his deposit, and having there exposed to them his merchandise, he will endeavor to open a forced or clandestine trade; for he observes, the Spaniards will not dare to attack his camp. Here you have the plan, and you must take all prudent and lawful means to blow it up.

In regard to your approximation to the Spanish settlements, should your route lead you near them, or should you fall in with any of their parties, your conduct must be marked by such circumspection and discretion as may prevent alarm or conflict, as you will be held responsible for consequences. On this subject I refer you to my orders. We have nothing new respecting the pending negotiations in Europe; but from Colonel [T. H.] Cushing I understand the Spaniards below are behaving now with great courtesy.

By the return of the bearer you may open your correspondence with the secretary of war [General Dearborn]; but I would caution you against anticipating a step before you, for fear of deception and disappointment. To me you may, and must, write fully and freely, not only giving a minute detail of everything past worthy of note, but also of your prospects and the conduct of the Indians. If you discover that any tricks have been played from St. Louis, you will give them to me with names, and must not fail to give particulars to the secretary of war, with names, to warn him against improper confidence and deception. Inclose your dispatch for me to Colonel [T.] Hunt, and it will follow me by a party which I leave for the purpose. It is interesting to you to reach Nachitoches in season to be at the seat of government pending the session of Congress; yet you must not sacrifice any essential object to this point. Should fortune favor you on your present excursion, your importance to our country will, I think, make your future life comfortable.

To show you how to correct your watch by the quadrant, after it has been carefully adjusted, preparatory to your observing the eclipses of the satellites of Jupiter, I send you a very simple plan, which you will readily understand: a basin of water, in some place protected from the motion of the air, will give you a fairer artificial horizon than mercury. I think a tent, with a suitable aperture in the side of it, would do very well. I have generally unroofed a cabin.

Miranda has botched his business. He has lost his two schooners captured, and himself in the Leander returned to Jamaica. The French have a squadron of four frigates at Porto Rico, and five sail of the line with Jerome Bonaparte at Martinique. I consider them lost.

Your children have been indisposed; but Mrs. Pike writes you. She appears well. My regards to your associates, and may God protect you.

[Signed] J. Wilkinson.

Lieutenant Pike.