Other effects of the epidemic of 1837-40 on medical opinion.

A second inoculation, except as a mere test of the first and within a few weeks thereof, was no part of the original 18th century teaching and practice. The theory of inoculation being based upon the familiar experience that we seldom have the same infectious disease twice in a lifetime, it was held that inoculation, if it were effective, was the giving of smallpox once for all, and that it could not really be given a second time unless the first inoculation had been ineffective. As soon as cowpox was recommended, it was remarked as a strange thing that this disease, according to current accounts of it, was actually acquired by milkers time after time. That fact in its natural history, said the Medical and Physical Journal of January, 1799, was “received with general scepticism merely on account of its improbability.” Dr Pearson was so troubled by the apparent inconsistency that he wrote to Dr Jenner in 1798 to ask whether it were really so; and although the latter confirmed the matter of fact, Pearson went on denying it, and did actually deny it as late as the Report of the Vaccine Pock Institution for 1803. Again, the report of the Whitehaven Dispensary for 1801, while it admitted the matter of fact, adverted to the anomaly in these words: “As we know from experience that the cowpock can be repeatedly introduced by inoculation, it appears remarkable that it can act as a preventive of a similar equally specific but more malignant disease.” Those were theoretical difficulties, which the practical minds of the profession did not stand upon. When we next hear of the possibility of having cowpox more than once, it is no longer an intellectual stumbling-block but is turned to account in the way of re-vaccination. Lapidem quem reprobaverunt aedificantes, hic factus est in caput anguli.

The practice of re-vaccination was usual on the Continent long before the English took to it. The reason of this was that a second inoculation of cowpox was not resorted to for the greater security of infants and young children, who were then the principal victims of smallpox in this country, but for the protection of adults, who made a great part of the subjects of the epidemics in other countries. There were so many adult deaths in the great Paris epidemic of 1825 that the news of it reads like the English references to smallpox in the time of the Stuarts. We obtain exact statistics of the ages in the 3323 fatal cases of smallpox in Paris from 1842 to 1851. Reduced to percentages they were as follows:

All ages 0-5 5-10 10-20 20-30 30-40 Over 40
100 33·8 5·9 13·25 32·95 10·95 3·15

Two-thirds of the deaths were above the age of five years, an age-incidence that was not reached in London until a whole generation after. The contrast with British experience comes out in concrete form in the following table of the age-incidence of 342 fatal attacks of smallpox in 1850 and 364 in 1851, in Paris (pop. 1,000,000), and of 584 fatal attacks in Glasgow in the single year 1852 (pop. 370,000)[1170]:

Age-incidence of fatal Smallpox in Paris and in Glasgow.

Paris, 1850-51
(706 deaths)		 Glasgow, 1852
(584 deaths)
Under one year 126 188
One to two 32 150
Two to five 94 189
Five to ten 31 20
Ten to fifteen 20 4
Fifteen to twenty 51 2
Twenty to twenty-five 109 19
Twenty-five to thirty 89 2
Thirty to forty 128 8
Forty to fifty 22 1
Over fifty 4 1

In other parts of the Continent of Europe the frequency of smallpox in adults was not less remarked than in France in the second quarter of the 19th century. English writers had been able at one time to point to foreign countries for the success of infantile vaccination. Sweden and Denmark were for a long time classical illustrations; then it was Germany’s turn. “In Berlin during 1821 and 1822,” said Roberton, “only one died of smallpox in each year. In the German States, vaccination has become universal, and in them as well as in various other countries the smallpox is almost unknown.” When we next find German experience appealed to, it is to enforce the need of re-vaccination: “In 1829,” said Gregory, “the principal Governments of Germany took alarm at the rapid increase of smallpox, and resorted to re-vaccination as a means of checking it. In Prussia, 300,000 had been re-vaccinated, and the same number in Würtemberg. In Berlin nearly all the inhabitants had undergone re-vaccination[1171].” It was about the same time that a second vaccination became obligatory in the armies of Prussia, Würtemberg, Baden and other German States, and among the pupils of schools when they reached the age of twelve years. Dr Gregory, in his speech at the Medical and Chirurgical Society of London in December, 1838, urged the need of re-vaccination not only by the example of Germany, but also by the experience of Copenhagen, where a thousand cases of smallpox had been received into the hospital (it was nearly always adults that were taken to the general hospitals) in twenty-one months of 1833-34, nine hundred of them being of vaccinated persons[1172]. Gregory was in advance of his age in advocating re-vaccination for England. His own cases at the Smallpox Hospital of London were, it is true, nearly all adults, according to the rules of the charity. But they were not representative even of the smallpox of the capital; and in England at large smallpox in 1839 was still distinctively a malady of the first years of life. It was not until youths and adults began to have smallpox in large numbers in the epidemic of 1871-72 that the doctrine of re-vaccination was generally apprehended in England. Medical truth, like every other kind of truth except that of geometry, is conditioned by time and place. What was a truth to the Germans in 1829 was not a truth to us until some forty years after. Dr Gregory, Sir Henry Holland and others advised re-vaccination after the epidemic of 1837-40; but as late as 1851 the National Vaccine Establishment denounced it as incorrect in theory and uncalled-for in practice.

After the great epidemic of 1837-40, there was an interval of a whole generation until smallpox broke out again on anything like the same scale, in 1871 and 1872. But it had risen to a considerable height at shorter intervals—in 1844-45, which were the years when vast numbers of navvies were employed making railroads all over England, in 1847 and successive years to 1852, which was the period of the great Irish migration after the potato-famine, in 1858, for which I find no explanation, and in the period from 1863 to 1865, which was again a time of somewhat high typhus mortality, not only in the Lancashire cotton-districts but also in London. The great epidemic of 1871 and 1872 finds no better explanation than our neighbourhood to Germany and Belgium, where the mortality from smallpox was far greater than in Britain, and was doubtless favoured by the state of war in 1870-71. The following tables for London, and for England and Wales in comparison with measles, scarlatina and diphtheria, show the progress of smallpox from the epidemic of 1837-40 to the present time:

Smallpox Deaths in London from the beginning of Registration.

Year Deaths
1837 (6 mo.) 763
1838 3817
1839 634
1840 1235
1841 1053
1842 360
1843 438
1844 1804
1845 909
1846 257
1847 255
1848 1620
1849 521
1850 499
1851 1062
1852 1150
1853 211
1854 694
1855 1039
1856 531
1857 156
1858 242
1859 1158
1860 898
1861 217
1862 366
1863 1996
1864 547
1865 640
1866 1391
1867 1345
1868 597
1869 275
1870 973
1871 7912
1872 1786
1873 113
1874 57
1875 46
1876 736
1877 2551
1878 1417
1879 450
1880 471
1882 430
1883 146
1884 898
1885 914
1886 5
1887 7
1888 5
1889 0
1890 3
1891 1
1892 11
1893 206

England and Wales: Deaths by Smallpox, Measles, Scarlatina and Diphtheria from the beginning of Registration.

Smallpox Measles Scarlet Fever Diphtheria
1837 (½) 5811 4732 2550 —
1838 16268 6514 5862 —
1839 9131 10937 10325 —
1840 10434 9326 19816 —
1841 6368 6894 14161 —
1842 2715 8742 12807 —
1847 4227 8690 14697 —
1848 6903 6867 20501 —
1849 4644 5458 13123 —
1850 4665 7082 13371 —
1851 6997 9370 13634 —
1852 7320 5846 18887 —
1853 3151 4895 15699 —
1854 2868 9277 18528 —
1855 2523 7354 16929 385
1856 2277 7124 13557 603
1857 3236 5969 12646 1583
1858 6460 9271 23711 6606
1859 3848 9548 19310 10184
1860 2749 9557 9681 5212
1861 1320 9055 9077 4517
1862 1638 9860 14834 4903
1863 5964 11340 30473 6507
1864 7684 8322 29700 5464
1865 6411 8562 7700 4145
1866 3029 10940 11683 3000
1867 2513 6588 12380 2600
1868 2052 11630 21912 3013
1869 1565 10309 27641 2606
1870 2620 7543 32543 2699
1871 23062 9293 18567 2525
1872 19022 8530 11922 2152
1873 2308 7403 13144 2531
1874 2084 12235 24922 3560
1875 849 6173 20469 3415
1876 2468 9971 16893 3151
1877 4278 9045 14456 2731
1878 1856 9765 18842 3498
1879 536 9185 17613 3053
1880 648 12328 17404 2810
1881 3698 7300 14275 3153
1882 1317 12711 13732 3992
1883 957 9329 12645 4218
1884 2216 11324 11143 5020
1885 2827 14495 6355 4471
1886 275 12013 5986 4098
1887 506 16765 7859 4443
1888 1026[1173] 9784 6378 4815
1889 23 14732 6698 5368
1890 16 12614 6974 5150
1891 49 12673 4959 5036
1892 431 13553 5618 6552
1893 1455 10764 6869 8918

The great epidemic of 1837-40 was the last in England which showed smallpox in its old colours. The disease returned once more as a great epidemic in 1871-72, after an interval of a whole generation (in which there had been, of course, a good deal of smallpox); but the epidemic of 1871-72 was different in several important respects from that of 1837-40. It was a more sudden explosion, destroying about the same number in two years (in a population increased between a third and a half) that the epidemic a generation earlier did in four years. It was an epidemic of the towns and the industrial counties, more than of the villages and the agricultural counties; it was an epidemic of London more than of the provinces; and it was an epidemic of young persons and adults more than of infants and children. The great epidemic of 1871-72 brought out clearly for the first time all those changes in the incidence of smallpox; but things had been moving slowly that way in the whole generation between 1840 and 1871. Experience subsequent to 1871-72 has shown the same tendency at work.

To begin with the changed incidence upon rural and urban populations, a glance down the following Table, will show that the counties marked *, with a smaller share in 1871-72, in a total of deaths in all England and Wales which was nearly the same as in the great epidemic a generation before, are nearly all those with a population more purely rural[1174]:

Incidence of the Smallpox Epidemics of 1837-40 (four years) and 1871-72 (two years) respectively upon the Counties of England and Wales.

1837-40 1871-72
England and Wales 41,253 42,084
Metropolis 6421 9698
*Surrey (extra-metr.) 383 231
*Kent (extra-metr.) 817 537
*Sussex 161 126
Hampshire 348 1103
*Berkshire 450 46
*Middlesex (extra-metr.) 418 306
*Hertfordshire 260 157
*Buckinghamshire 268 53
*Oxfordshire 199 109
Northamptonshire 399 563
*Huntingdonshire 65 14
Bedfordshire 125 128
*Cambridgeshire 400 175
*Essex 773 583
*Suffolk 506 348
*Norfolk 1038 895
*Wiltshire 548 85
*Dorsetshire 329 163
*Devonshire 1097 838
*Cornwall 767 531
*Somersetshire 1466 412
*Gloucestershire 1072 323
*Herefordshire 191 34
*Shropshire 345 161
*Worcestershire 1002 529
Staffordshire 1328 3050
*Warwickshire 957 785
Leicestershire 528 622
Rutlandshire 8 7
Lincolnshire 482 498
Nottinghamshire 562 983
*Derbyshire 329 297
*Cheshire 1141 310
†Lancashire 7105 4151
†Yorkshire W. Riding 2858 2609
"E. Riding 480 452
"N. Riding 236 405
Durham 798 4767
Northumberland 569 1512
*Cumberland 549 366
*Westmoreland 98 41
Monmouthshire 672 904
*Wales 2699 2314

The counties which were most lightly visited in 1871-72, as compared with 1837-40, were the agricultural and pastoral. In the outbreaks subsequent to 1871-72, smallpox has almost ceased to be a rural infection in Scotland and Ireland as well as in England. The great change that has come over it in that respect is shown in the following table, in which the annual death-rates from smallpox per 100,000 living are contrasted, for children under five, in each of several agricultural counties, with the mean of all England and of London, 1871-80, and with the corresponding scarlatinal death-rates in the right-hand column:

Annual Death-rates of Children under five, per 100,000 living, 1871-80.

Smallpox Scarlatina
All England 53 349
London 113 307
Sussex 9 100
Berkshire 4 141
Bucks 4 160
Oxfordshire 9 167
Huntingdonshire 3 205
Bedfordshire 11 242
Cambridgeshire 18 112
Suffolk 12 136
Wiltshire 5 210
Dorsetshire 15 152
Herefordshire 5 166
Shropshire 12 247

But the history of smallpox since the great epidemic of 1871-72 has brought out still another tendency in the same direction, namely, the increasing share of London in the whole smallpox of England. In the epidemic of 1837-40, which reached to almost every parish of England and Wales, London had 6449 deaths in a total of 41,644, or between a sixth and a seventh part, having rather less than an eighth part of the population. In the epidemic of 1871-72, London had between a fourth and a fifth part of the deaths (9698 in a total of 42,084), having then about a seventh part of the population. In 1877, more than half of all the smallpox deaths were in London, and in the year after as many as 1417 in a total of 1856. In 1881, London had about two-thirds of the deaths from smallpox in all England and Wales; but in the epidemic of 1884-85, it had only over a third part (1812 in a total of 5043). This excess of London’s share over that of the provinces is expressed in the following table, showing the respective rates of smallpox mortality per million of the population:

Smallpox Deaths in London and the Provinces, per million of population.

1847-9 1850-4 1855-9 1860-4 1865-9 1870-4 1875-9 1880-4
London 460 300 237 281 276 654 292 244
Provinces 274 271 192 175 172 339 48 34

If the table were continued to the very latest date, it would show the provinces recovering their share, but upon a slight prevalence of the epidemic as a whole, the deaths in London having been mere units from 1886 to 1892, while in 1888 there was a severe epidemic in Sheffield and in 1892-93 a good deal of the disease in a few manufacturing towns of the North-western and Midland divisions. It would be a not incorrect summary of the incidence of smallpox in Britain to say, that it first left the richer classes, then it left the villages, then it left the provincial towns to centre itself in the capital; at the same time it was leaving the age of infancy and childhood. Of course it did none of these things absolutely; but the movement in any one of those directions has been as obvious as in any other. Measles and scarlatina have not shown the same tendency to change or limit their incidence. Smallpox may have surprises in store for us; but, as it is an exotic infection, its peculiar behaviour may not unreasonably be taken to mean that it is dying out,—dying, as in the death of some individuals, gradually from the extremities to the heart.

With all those changes, the fatality of smallpox, or the proportion of deaths to attacks, came out in the great epidemic of 1871-72 curiously near that of the 18th century epidemics, namely, one death in about six cases. This rate comes from the hospitals of the Metropolitan Asylums Board according to the following table:

Admissions for Smallpox, with the Deaths, at the hospitals of the Metropolitan Asylums Board, from the opening of the several hospitals to 30 April, 1872.

Males Females Both Sexes
Age-periods Adm. Died Percentage
of deaths		 Adm. Died Percentage
of deaths		 Adm. Died Percentage
of deaths
Under 5 434 235 54·15 469 236 50·32 903 471 52·15
5-10 851 236 27·73 821 196 23·87 1672 432 25·83
10-20 2827 265 9·37 2513 237 9·43 5340 502 9·40
20-30 2561 465 18·15 1922 285 14·82 4483 750 16·72
30-40 939 244 26·00 665 136 20·45 1604 380 23·69
40-50 316 100 31·64 242 64 26·45 558 164 29·39
50-60 85 18 21·17 88 31 35·22 173 49 28·32
Above 60 40 8 20·00 35 7 20·00 75 15 20·00
8053 1571 19·49 6755 1192 17·64 14,803 2763 18·65

These admissions to hospitals included attacks of every degree of severity, the intention of the hospitals being to isolate all cases, mild and severe alike; so that, although these are technically hospital cases, they are not comparable to the select class admitted to the old Smallpox Hospital of London, but to the cases of smallpox in former times in the community at large. Although the general average of deaths in 14,808 cases, namely, 18·65 per cent., is nearly the same as (being slightly higher than) that of the equally comprehensive totals of 18th century cases given at p. 518, yet the average is made up in a different way. In some of the 18th century epidemics, such as that of Chester in 1774, all the deaths were under ten years of age, and yet the average rate of fatality was only 14 or 15 per cent. The much higher rate of fatality from birth to five years and from five years to ten in the London epidemic of 1871-72 (which is confirmed in part by the Berlin statistics of the same years), must have had some special reasons. One reason, doubtless, was that the attack of smallpox in recent times has fallen upon comparatively few children, whereas in former times it fell upon nearly the whole; and it may be inferred that the infants who have been in recent times subject to the attack of smallpox have also been of the class that are most likely to die of it. The high rates of fatality at the ages above thirty in the table agree with the experience of all times.

The percentages of fatalities from smallpox in the hospitals of the Metropolitan Asylums Board have varied as follows from their opening to the present time:

Cases Percentage
of deaths
1 Dec. 1870-3 Feb. 1871 582 20·81
4 Feb. 1871-31 Jan. 1872 13,145 18·95
1872-3 2362 17·84
1873-4 191}
}		17·02
1874 (11 mo.) 120
1875 111
1876 2150 21·64
1877 6620 17·92
1878 4654 17·99
1879 1688 15·69
1880 2032 15·95
1881 8671 16·61
1882 1854 12·96
1883 626 16·06
1884 6567 15·98
1885 6344 15·8
1886 132}
}
}
}		14·28
1887 59
1888 67
1889 5
1890 27
1891 64
1892 348 11·29
1893 2376 7·75

The decline in average fatality in the last two years is remarkable, and is to be explained chiefly by the mild type of smallpox which has been prevalent; a very small fraction of the patients attacked between the ages of ten and twenty-five have died; and these are some two-fifths of the whole. This is shown in the following age-table of 2374 cases admitted to the Metropolitan Board Hospitals in 1893:

Smallpox in London, 1893.

Age-period Cases Deaths %
0-5 168 53 31·5
5-10 191 16 8·3
10-15 230 7 3·0
15-20 340 7 2·0
20-25 393 13 3·3
25-30 298 23 7·7
30-35 250 14 5·6
35-40 182 13 7·1
40-50 199 18 9·0
50-60 79 9 11·4
60-70 35 6 17·1
70-80 9 1 11·1

The low rate of fatality during the slight epidemic revival of smallpox in 1892-93 has been found to obtain wherever the disease has occurred:

Smallpox in the Provinces, 1892-93.

Cases Deaths Fatalities
per cent.
Birmingham 1203 96 8
Warrington 598 60 10
Halifax 513 44 8·5
Manchester 406 27 6·7
Glasgow 279 23 8·2
Liverpool 194 15 7·7
Brighouse 134 15 11·2
Aston Manor 113 6 5·3
Leicester 362 21 5·8
St Albans 58 6 10·4
3860 313 8·10

The ages under ten years had only 290 in 3644 of these cases; but those 290 cases had 70 in 302 of the deaths.

In the comparative table for Ireland, of deaths by smallpox, measles, scarlatina and diphtheria, measles in a decreasing population has changed little, while scarlatina has declined greatly, and smallpox has fallen during the last ten years almost to extinction.

Ireland: Deaths by Smallpox, Measles, Scarlatina and Diphtheria from the beginning of Registration.

Smallpox Measles Scarlatina Diphtheria
1864 854 630 2605 661
1865 461 1036 3683 480
1866 194 851 3501 317
1867 21 1292 2145 189
1868 23 1251 2696 202
1869 20 948 2670 243
1870 32 954 2978 188
1871 665 547 2707 226
1872 3248 1380 2459 257
1873 504 1303 2092 326
1874 569 667 4034 565
1875 535 898 3845 443
1876 24 664 2112 368
1877 71 1562 1117 288
1878 873 2212 1079 296
1879 672 860 1688 320
1880 389 1025 1344 314
1881 72 402 1230 323
1882 129 1518 2443 385
1883 16 801 1765 239
1884 1 559 1377 354
1885 4 1323 1147 296
1886 2 284 850 336
1887 14 1307 973 381
1888 3 1935 849 447
1889 0 574 457 358
1890 0 726 319 346
1891 7 240 308 281
1892 0 1183 419 286

In the great Irish famine of 1846-49, comparatively little is heard of smallpox. It would appear to have been less diffused through the country than in former famines, such as that of 1817-18, or those of the first part of the 18th century, just in proportion as the vagrancy of famine-times was checked by the establishment of workhouses. In the workhouses and auxiliary workhouses during the ten years 1841-51, smallpox is credited with 5016 deaths, while measles has 8943, fever 34,644, dysentery 50,019, diarrhoea 20,507, and Asiatic cholera 6716. Registration began in Ireland in 1864, and showed little smallpox for the first few years. The next great epidemic, of 1871-72, showed the incidence upon the large towns, and the comparative immunity of the country population, even more strikingly than in England. In a total mortality of 3913 during the two years of 1871 and 1872, the three counties of Dublin, Cork and Antrim had the following enormous share, which fell mostly to the three cities of Dublin, Cork and Belfast:

Dublin Co. 1825
Cork Co. 1070
Antrim 510
3405 deaths in 3913 for all Ireland.

In that epidemic the whole province of Connaught had only 25 deaths from smallpox; but a subsequent visitation, a few years after, fell mainly upon Connaught.

The epidemic which began in Scotland in 1871 was distributed over a somewhat longer period than the corresponding outbreak in England; but the bulk of it fell in the two years 1871 and 1872. The total of 3890 deaths in those two years was distributed as follows:

Eight largest towns 2441
Next largest towns 259
Small town districts 574
Mainland rural districts 586
Insular rural districts 30
3890

Glasgow had a considerably smaller relative share than Edinburgh, and altogether a much lighter incidence of the disease than in the years 1835-52, for which the figures have been given above (pp. 600-1). In the following table of the annual deaths in Scotland from the beginning of registration, the four other infective diseases of childhood included along with smallpox show by comparison the remarkable decline of smallpox since 1874, scarlatina being the only other infection of childhood which has become greatly less common or less fatal.

Scotland. Deaths by Smallpox, Measles, Scarlatina, Diphtheria and Whooping-Cough, from the beginning of Registration.

Smallpox Measles Scarlatina Diphtheria Whooping-Cough
1855 1209 1180 2138 — 1903
1856 1306 1033 3011 — 2331
1857 845 1028 2235 76 1539
1858 332 1538 2671 294 1963
1859 682 975 3614 415 2660
1860 1495 1587 2927 480 1812
1861 766 971 1764 681 2204
1862 426 1404 1281 997 2799
1863 1646 2212 3413 1745 1649
1864 1741 1102 3411 1740 1993
1865 383 1195 2244 995 2318
1866 200 1038 2706 685 1860
1867 100 1341 2253 610 1728
1868 15 1149 3141 749 2490
1869 64 1670 4680 663 2461
1870 114 834 4356 630 1783
1871 1442 2057 2586 880 1504
1872 2448 925 2101 1045 2850
1873 1126 1450 2227 1203 1598
1874 1246 1103 6321 1163 1690
1875 76 1022 4720 867 2431
1876 39 1241 2364 861 2250
1877 38 1019 1374 956 1571
1878 4 1372 1870 1033 2788
1879 8 769 1592 862 2483
1880 10 1427 2165 838 2641
1881 19 1012 1573 816 1620
1882 3 1289 1583 961 2108
1883 11 1629 1336 747 2968
1884 14 1440 1266 830 2511
1885 39 1426 944 688 2157
1886 24 681 1058 583 1882
1887 17 1598 1179 805 3212
1888 3 1406 732 872 1722
1889 8 1948 701 968 2268
1890 0 2509 739 1018 3039
1891 0 1775 736 830 2437