Toadstools, mushrooms, fungi, edible and poisonous; one thousand American fungi / How to select and cook the edible; how to distinguish and avoid the poisonous, with full botanic descriptions. Toadstool poisons and their treatment, instructions to students, recipes for cooking, etc., etc.

by Charles McIlvaine; Robert K. Macadam

ANTIDOTAL VALUE OF ATROPINE.

In arriving at any conclusion we must bear in mind the variation of different animals in their susceptibility to poisons. Thus, to give the greatest difference observed, .085 gram. dried Amanita muscaria per kilo of body weight killed one dog in an hour, while in another dog .223 grams. of the same preparation per kilo only killed after 24 hours, the cardiac inhibition having disappeared one-half hour after the poison was injected. However, an average of six (6) experiments on cats and dogs with dried A. muscaria in which no antidote was given shows the lethal dose to be .103 gram. per kilo of body weight. The average of four (4) experiments, in which the fungus, dried in the same way, was used but atropine was given as an antidote, gives the lethal dose of .335 gram. per kilo and death only occurred late in each case. There can be no doubt, therefore, of the antidotal value of atropine for poisoning by Amanita muscaria.

It should be borne in mind, however, that it is not an infallible antidote even when given early, and that it does not prevent death from the late effects in severe cases, although given in large doses. In some experiments atropine was administered at the same time the poison was given and in others before it.

The important practical lesson is that too much reliance should not be placed upon atropine. It will be shown later that it has little value as an antidote to A. verna and A. phalloides. Probably these fungi contain less muscarine than A. muscaria. Although there is no drug so antagonistic in its physiological action to the poison of the A. muscaria as atropine, the use of other remedies should not be neglected. The symptoms have to be treated as they arise. Strychnia, alcohol in moderate amounts and suprarenal extract could all be used to advantage in restoring the circulation, especially late in the poisoning. Atropine merely removes the inhibition of the heart which occurs as an early symptom.

External heat should be applied if the body temperature is subnormal. The treatment of gastro-intestinal symptoms will depend upon the conditions of each individual case. The injection of a large amount of warm physiological salt solution (.6-.7 per cent. sodium chloride) into the subcutaneous tissues should also be tried in severe cases seen late in the poisoning.