Strychnine:
Symptoms: It all depends how the agent has been administered how quickly it acts. If in a liquid form, the symptoms may commence in ten minutes, or quicker; but if it has been given in a piece of meat, it may be an hour or so before any signs appear. Then the animal becomes restless; the limbs are stiff, and the dog walks with difficulty, and with the hind legs stretched apart. Occasionally there is a violent twitching or jerk of all the muscles of the body, as if the dog had a galvanic shock, and then he suddenly falls to the ground, often in a forward direction, and in acute tetanic spasm. The limbs are extended, and as stiff as pieces of iron, the fore ones in a slightly forward direction, and the hind legs in a backward direction. The head is drawn back, and the back arched and the tail extended and stiff; the eyes protrude, the mouth firmly closed, and the pulse extremely quick. Respiration during the spasm, which lasts about half a minute or so, entirely ceases. At the end of the attack the dog gives a few heavy sighs, and then commences to pant hard. The least movement or touch, or even a noise, will cause a return of the convulsions, which continue at frequent intervals, unless the dog is relieved by some suitable antidote, or until death occurs, which generally takes place during a paroxysm. In some cases, though the acute symptoms may have been checked by treatment, the dog afterwards dies from the effect of the exhaustion.
Treatment: In all cases of poisoning, more especially when due to strychnine, prompt action is required, and means should at once be taken to make the dog disgorge what has been swallowed. An emetic that will act well and quickly must be at once administered; for this there is nothing better than a dose of hydrochlorate of apomorphia. This medicine acts in two ways: it is the quickest and surest emetic; and besides, it relieves the spasms. The dose is the twelfth of a grain for small dogs, and about a quarter of a grain for large ones, given in a teaspoonful of water; but the best way of administering it is by injecting it under the skin with a hypodermic syringe; then from three[1] to ten minims of the one in fifty solution is to be given. I always advise persons who keep a number of valuable dogs to have a solution of apomorphia by them ready for emergency, for whilst it is being obtained the patient may die, and if huntsmen would always carry a small bottle of the solution with them many a valuable hound’s life might be saved. When this medicine is not at hand, some other emetic must be given. Ordinary table salt can always be quickly procured, and from one teaspoonful[1] to a tablespoonful should be given in warm water. If the dose does not act freely, repeat it in a few minutes; or instead, give from five[1] to twenty grains of powdered ipecacuanha, or from half[1] to three grains of tartar emetic. Either of these may be shaken dry on the tongue. The dog must be made to vomit somehow; but anything like salt, requiring a quantity of water, is difficult to administer, as the dog’s mouth is often tightly clenched, and trying to open it induces paroxysm, during which time it is impossible to give anything by the mouth; and here the advantage of the subcutaneous injection of apomorphia comes in. This may also be repeated in a quarter of an hour, if the vomiting has not been free. Besides the emetic, some medicine is necessary to relieve the spasms. For this there is nothing better than chloral and bromide of potassium. From fifteen[1] grains to two scruples of each may be given in from one[1] to three tablespoonfuls of water, if the dog can be made to swallow; and half the quantity of each may be given again in twenty or thirty minutes, and repeated, if necessary, in half an hour. When the dog is unable to swallow, from two[1] to six minims of nitrite of amyl, held to the nose on a pocket-handkerchief, is useful. This may be repeated in a quarter of an hour, or chloroform may be given. Also, inject into the rectum from one[1] half to two drachms of laudanum in from one[1] to four tablespoonfuls of water, which repeat in a quarter of an hour, and again in another fifteen minutes if the paroxysms continue.
After the severe symptoms have passed, and the dog is weak and prostrate, from a quarter[1] to two teaspoonfuls of brandy added to some milk may be administered, and repeated every half hour for a time.
Arsenic:
Symptoms: The dog, shortly after taking the poison, becomes restless. Violent sickness soon commences, the vomited matter being mixed with blood. There is also acute diarrhœa, accompanied by severe straining, and a good deal of blood is often passed with the motions. The dog is extremely thirsty, has an anxious countenance, showing evident signs of great pain, and breathes heavily. There may be severe convulsions, followed by paralysis, collapse, and death.
Treatment: The vomiting at first should be encouraged by giving an emetic, as three[1] to ten drops of the one in fifty solution of apomorphia with a hypodermic syringe. If this is not at hand, give from the twelfth[1] to a quarter of a grain of the same medicine in a teaspoonful of water. Failing the apomorphia, give from five[1] to twenty grains of sulphate of zinc in a little warm water, or even salt and water. The vomiting may be kept up by getting the dog to drink warm water. Besides endeavouring to free the stomach of all the arsenic, an antidote is required to remedy the ill effect of the poison. For this there is nothing better than dialysed iron given in large doses, as from half[1] a teaspoonful to a tablespoonful every half hour until several doses have been given. This may be followed by a large dose of castor oil. About an hour afterwards some carbonate of bismuth should be given, shaken dry on the tongue, from ten[1] grains to a drachm, which may be repeated every hour or two. When there is great prostration, stimulants, as brandy, are required, and when the patient is unable to swallow or retain it in the stomach, from one[1] half to a drachm may be injected under the skin frequently. If the body is cold wrap the dog up in hot blankets, and place hot-water bottles around him. As improvement takes place, milk thickened with arrowroot, barley, or rice water may be given. If the dog appears in much pain after the acute stage has passed, small doses of laudanum may be given, and hot linseed poultices applied to the stomach.
In chronic cases of poisoning by arsenic—a not uncommon occurrence, as this is a favourite remedy for skin diseases, and too much is often given, or the medicine is given too long—the dog loses appetite and condition, becomes very weak and emaciated, frequently vomiting a white, frothy mucus as well as food.
There is often severe diarrhœa, and blood is passed with the motions. There are signs of tenderness on pressure over the region of the stomach, and excessive thirst. The membrane (conjunctiva) lining internal surface of eyelids is red and congested.
Treatment: Discontinue the use of the arsenic immediately, give tonics, as reduced iron, from one[1] to three grains made into a pill with an extract of gentian. If the sickness continues, give from three[1] to ten grains of carbonate of bismuth, shaken dry on the tongue, every three or four hours.