The salts of quinine may be made by simply saturating the dilute acids with the base, so that part of the latter remains undissolved, and gently evaporating the solutions for crystals, or to dryness. Prince Lucien Bonaparte recommends all these salts to be prepared by the addition of a strong alcoholic solution of quinine to a cold solution of the acid. We have tried this method with success.
Quinine, Ac′etate of. Syn. Quinæ acetas, L. Prep. 1. (P. Cod.) Mix quinine, 2 parts, with water, 3 parts; heat the mixture, and add of acetic acid, q. s. to dissolve the alkaloid, and to render the solution slightly acid; lastly, decant or filter the solution whilst boiling hot, and set it aside to crystallise. The mother water, on evaporation, will yield a second crop of the acetate.
2. Effloresced sulphate of quinine, 17 parts, is dissolved in boiling water, and mixed with crystallised acetate of soda, 6 parts. The acetate of quinine crystallises.
Prop., &c. Satiny, acicular crystals, which are rather more soluble in water than those of the sulphate.—Dose, 1⁄2 to 5 grains.
Quinine, Arse′′niate of. Syn. Quinæ arsenias, L. Prep. (Bourières.) Arsenic acid, 11⁄2 dr.; quinine, 5 dr.; distilled water, 6 fl. oz.; boil them together in a covered glass vessel until the alkaloid is dissolved, then set the solution aside to crystallise.
Uses, &c. Recommended by Dr Neligan, and others, as being more powerfully antiperiodic than the other preparations of quinine.—Dose, 1⁄12 to 1⁄4 gr., made into pills; in agues, neuralgia, &c.; also in cancer.
Quinine, Ar′senite of. Syn. Quinæ arsenis, L. Prep. Sulphate of quinine, 100 parts, is dissolved in alcohol, 600 parts, and boiled with arsenious acid, 14 parts. The liquid is then filtered. The poisonous salt is deposited in the crystalline form as the liquid cools.
Uses, &c. As the last.
Quinine, Chlo′′ride of. Hydrochlorate of quinine (see below).
Quinine, Ci′trate of. Syn. Quinæ citras, L. Prep. 1. By mixing a hot solution of sulphate of quinine with a like solution of citrate of soda.