The action of the stomach in digestion, appears, therefore, so far as our actual knowledge extends, a purely catalytic fermentative action; one in which the active excitant is an organic substance (pepsine), secreted by the mucous surface, and whose properties are developed by the presence of muriatic acid, which is secreted at the same time. The new products into which the food, fibrine, albumen, gluten, starch, oils, sugar, etc., are converted, and which collectively constitute the white uniform pulp, termed by physiologists chyme, have not been made the subject of accurate chemical researches.
In the mouth the mass of nutritive material is acted on by a liquid which is secreted by the salivary glands, the saliva. It is alkaline, and holds in solution not one per cent. of solid matter, which contains some carbonate of soda and common salt, admixed mucous, and a peculiar organic body, termed salivary matter.
This last substance is soluble in water; its solution is not coagulated by heat, nor precipitated by tincture of galls, corrosive sublimate, acetate of lead, nor by acids. The pancreas, so similar in structure to the salivary glands, has a different secretion; it contains no salivary matter, but albumen and some salts; it is generally slightly acid.
Composition of the Bile.—The precise part which this remarkable secretion performs in the animal economy is not yet fully known; it has been the subject of repeated and accurate chemical examination, although, from the facility with which its elements are transferred into other bodies, by the action of the reagents employed, every succeeding analysis has led to different results.
The Coloring matter of the Bile.—is present during health but in small quantity, but in disease it sometimes accumulates so as to form solid masses. When pure, it is a reddish-yellow powder, which is scarcely soluble in water or in alcohol, but dissolves easily in a solution of caustic potash. This solution is of a clear yellow color, but when exposed to the air it becomes deep green, absorbing oxygen. This change is remarkably produced by nitric acid, and it is indeed the reaction by which the presence of the bile in the serum of the blood, in the skin, in the urine, and eyes, etc., may be shown in cases of jaundice.
Chyle and Lymph.—The nutritive materials extracted from the food by the absorbing vessels of the intestines, is thrown into the thoracic duct, where it meets with another fluid, which is transmitted to the same vessel from all parts of the body by the colorless veins or lymphatics. The fluid from the intestines is termed chyle; that from the body is generally termed lymph. It is the mixture of these that has alone been examined, for the vessels which carry either separately are too minute to allow of the extraction of their contents in a pure form.
When taken from the thoracic duct, a few hours after a meal, when, probably, the chylous element prevails, it is whitish, opaque, liquid, like milk, with generally a reddish shade; a short time after separation from the body, it coagulates; the clot is at first pale, but it soon becomes light crimson red; the milkiness of the serum is due to the presence of oil; it contains albumen, and coagulates by heat; except that it is more dilute, and that the hematosine is for the most part absent, the chyle and lymph have the same composition as the blood. It appears to vary, however, with the nature of the food, as Dr. Prout found the chyle of persons fed on vegetables to contain a much smaller quantity of albumen than when they had had animal food.
Dr. Prout also indicates in chyle the presence of a substance which he terms incipient albumen, which is not coagulated by heat, except after the addition of acetic acid; the properties of this form of albumen, however, are not fully known.
Constitution of the Urine in Health and Disease.—The nature of this secretion has at all times been an object of considerable interest to the chemist, from the indications which changes in its composition give of diseases of important organs and from the number and interest of the different organic substances it contains. As in almost all other branches of animal chemistry, Burzelius first determined its composition, and lately Lecaner has ascertained with great care the limits to which the proportions of its ingredients may vary in health, and this established a correct basis of comparison for urine in the various conditions of diseases.
Of the Urine in Disease and after Death—Urinary Calculi.—To the chemist, the indications of disease of the urinary and digestive organs, formed by changes in the composition of urine, are most valuable. The majority of the substances which are taken into the circulation, but are incapable of assimilation to our organs, are thrown off by this secretion, and hence a variety of medicinal substances may be traced to it after having been ingested, sometimes quite unaltered, at others modified in their natures. Thus if alkaline salts of organic acids be taken into the stomach, the organic material is oxidized, probably during the action of respiration, while the alkali passes into the urine in the state of carbonate. If, however, the organic acid be taken uncombined, it escapes decomposition, and, passing into the urine, produces an abundant precipitate of salts of lime. In the case of the tartaric acid and oxalic acids, some organic bodies, as aspharagine and the oil of turpentine, are decomposed, and the products which they form are execreted, giving to the urine peculiar odors; in the latter case like that of violets.