Experiment 17.—Toxic and virulent action of eucalyptus.—Three normal guinea-pigs were selected for the experiment, as in Experiment 16. The injection was made in the pleural cavity. Guinea-Pig 1 was injected with 0.5 c.c. and Guinea-Pig 2 with 1 c.c. of eucalyptus oil.
Result: Guinea-Pig 1 died the following day, and Guinea-Pig 2 one hour after the injection.

Experiment 18.—Toxic and irritant action of dichloramin-T, 0.5 per cent. in chlorcozane.—One guinea-pig was used for each experiment. Guinea-Pig 1 was injected with 0.5 c.c. and Guinea-Pig 2 with 1 c.c. of dichloramin-T peritoneally.
Result: Both animals became restless immediately after the injection, and died twelve hours after of acute hemorrhagic peritonitis.

Experiment 19.—Effect of chlorlyptus on staphylo­coccus suspended in salt solution and one of that solution injected into the peritoneum of the guinea-pig.—Three guinea-pigs were used for the experiment. Guinea-Pig 1 was injected with 0.5 c.c. of staphylo­coccus suspension as control. Guinea-Pig 2 was given the same, and immediately after received 1 c.c. of chlorlyptus. Guinea-Pig 3 was injected with the same amount, and chlorlyptus was injected twenty-four hours after injection.
Results: Guinea-Pig 1 was sick and weak with loss of appetite for some days, but gradually recovered. Guinea-Pig 2 died over night.
Autopsy: There was a large amount of exudate in the peritoneal cavity, irritation of the intestine, and other signs of acute inflammation. A moderate degree of congestion; spleen not enlarged; liver showed cloudy swelling and fibrinous exudate; lungs and heart about normal except for a moderate degree of congestion but no exudate. Guinea-Pig 3 was sick for some days, but recovered gradually one week after.

Experiment 20.—Effect of chlorlyptus in vivo on staphylo­coccus.—The experiment was conducted in the same way as in Experiment 17, but 2 c.c. were used instead of 1 c.c.
Result: Guinea-Pig 1 was injected with 2 c.c. staphylo­coccus suspension and died over night. Autopsy showed that the animal died of acute peritonitis. The peritoneum showed some fibrinous exudate and mesenteric vessels. Guinea-Pig 2 was injected with 2 c.c. of staphylo­coccus, and eighteen hours after was injected with 1 c.c. of chlorlyptus. The animal died two weeks after injection. Guinea-Pig 3 was injected with 2 c.c. staphylo­coccus suspension, and twenty-four hours after with 1 c.c. of chlorlyptus. The Guinea-Pig died ten days after. Autopsy revealed bronchopneumonia of the left lung and acute miliary abscess in the liver.

—(From The Journal A. M. A., Nov. 27, 1920, with additions.)

AQUAZONE (OXYGEN WATER)

Report of the Council on Pharmacy and Chemistry

Aquazone is stated by the Aquazone Laboratories, Inc., Los Angeles, California, to be a supersaturated solution of oxygen in water, carrying approximately five and one-half times as much dissolved oxygen as ordinary water. In an advertising booklet, it is suggested that Aquazone is of value in the treatment of influenza, pneumonia, typhoid, Bright’s disease and kindred disorders. It was also stated therein that in the treatment of fevers it lowers the temperature, and that the administration of three bottles of Aquazone (representing 0.033 gm.—11⁄2 grain—of oxygen) is of value for “preventive and tonic purposes.”