When the English first came to Madras, there were numerous Roman Catholic churches in the neighbouring Portuguese settlement of San Thomé, but there were none within the tract of land that Mr. Francis Day acquired in the Company's behalf. When, therefore, at the Company's invitation, a number of Portuguese from San Thomé, both pure-blooded and mixed, came and settled down in the Company's White Town, they were necessarily compelled to resort to the ministrations of Portuguese priests who belonged to the San Thomé Mission; and within a year of the foundation of Fort St. George, the Portuguese missionaries built a church in the outskirts of the British settlement. This was the Church of the Assumption, which stands in what is still called 'Portuguese Street' in Georgetown, and is therefore a building of historic note. To the Company's representatives the ministrations of Portuguese priests to residents of Madras were objectionable; for the relations between Madras and San Thomé were by no means friendly. It is true that when Mr. Francis Day was treating for the acquisition of a site, the Portuguese at Mylapore had furthered his efforts; but such a mark of apparent good will was no more than the outcome of Portuguese hostility to the Dutch; for they hoped that the English at Madras would be powerful allies with themselves against the aggressive Hollanders. As soon, however, as Madras had begun to be built and English trade to be actively pushed, jealousies arose and disagreements occurred; and the Company's representatives chafed at the idea that Portuguese priests should be the spiritual advisers of residents of Madras.

In 1642, when Madras was in its third year, a certain Father Ephraim, a French Capuchin, chanced to set foot in Madras. Father Ephraim had been sent out from Paris as a missionary to Pegu; and he had travelled across India from Surat to Masulipatam, where, according to his instructions, he was to have secured a passage to Pegu in one of the Company's ships. His information was out of date; for the Agency had lately been transferred from Masulipatam to Madras, and the Company's ships for Pegu were sailing now from Madras instead of from Masulipatam; so Father Ephraim journeyed southward from Masulipatam to look for a vessel at the new settlement. At Madras no vessel was starting immediately, and Father Ephraim had to bide his time. Meanwhile he made himself useful by ministering to the Roman Catholics of the place. Official and other documents show that Father Ephraim was a very devout and a very able man. He was 'an earnest Christian,' 'a polished linguist,' able to converse in English, Portuguese and Dutch, besides his own French, and he was conversant with Persian and Arabic. He had the charm of attractive friendliness, which is so common with Frenchmen, and he captivated all with whom he conversed. The Portuguese and other Roman Catholic inhabitants of Madras, to whom the Company's disapproval of the ministrations of Portuguese priests had been a frequent source of trouble, formally petitioned Father Ephraim to settle down in the city; and the Governor in Council, greatly preferring a French priest to a Portuguese and thoroughly approving of Father Ephraim personally, supported the petition with a formal order that, if the priest would stay, a site would be provided on which he might build a church for his flock. Father Ephraim himself was not unwilling to stay, but he was under orders for Pegu, and, furthermore, Madras was within the diocese of San Thomé, and the Bishop was not likely to approve of a scheme in which the ministrations of his own priests would be set at naught in favour of a stranger. The Company, however, was influential. A reference was made to Father Ephraim's Capuchin superiors in Paris, and they approved of his remaining in Madras; another reference was made to Rome, asking that the British territory of Madras should be ecclesiastically separated from the Portuguese diocese of Mylapore, and the Pope issued a decree to that effect.

A site for a church, as also for a priest's house, was provided in White Town, within the Fort St. George of to-day, and a small church, dedicated to St. Andrew, was built; and for a good many years it was the only church of any kind in the settlement.

The Portuguese ecclesiastics of Mylapore were never reconciled to this ecclesiastical separation of Madras, and when Father Ephraim went by invitation to Mylapore to discuss certain ecclesiastical business, he was forthwith arrested, clapped in irons, and shipped off to Goa and lodged in the prison of the Inquisition. The Governor of Fort St. George took the matter in hand, but Father Ephraim was in prison more than two years before he was eventually released and sent back to Madras.

Later, Father Ephraim rebuilt St. Andrew's Church on a larger plan, and the building was opened with ceremony; and Master Patrick Warner, the Company's Protestant Chaplain at Fort St. George, complained indignantly to the Directors in England that Governor Langhorn had celebrated the popish occasion with the 'firing of great guns' and with 'volleys of small shot by all the soldiers in garrison.'

Father Ephraim had already built a church in old Black Town, which seems to have stood somewhere within what is now the site of the High Court. Another French Capuchin had meanwhile come to Madras to help him in his ministrations to his ever-increasing flock; so the church in Black Town had its regular pastor.

After more than fifty years of self-sacrificing work in Madras, Father Ephraim died of old age, sincerely esteemed by all who knew him.

Some years after his death St. Andrew's was again rebuilt, and it was now a large edifice, with a high bell-tower, and a small churchyard around. In the suburban district of Muthialpet there was also a 'Portuguese Burying Place,' which is now the 'compound' of the Roman Catholic Cathedral and its associated buildings in Armenian Street; and a small church stood within this enclosure. Adjoining the Portuguese Burying Place was the 'Armenian Burying Place,' which is now the enclosure of the Armenian church; and it was the Armenian Burying Place that gave the name to the street.

When Madras was captured by the French, there were people who said that the French priests in Madras had given information to their countrymen; and three years later, when Madras was restored to the Company, the Governor in Council confiscated St. Andrew's church. A reference to the Directors in England as to what they were to do with the confiscated building brought back the very decisive reply that they were "immediately on the receipt of this, without fail to demolish the Portuguese Church in the White Town at Madras, and not suffer it to stand." The church was demolished accordingly, as also a Roman Catholic chapel in Vepery. The church in old Black Town had already been demolished by the French when they destroyed the greater part of old Black Town itself; and, in accordance with another edict of the Directors in England, by which the Company's representatives in Madras were "absolutely forbid suffering any Romish Church within the bounds, or even to suffer the public profession of the Romish religion," Roman Catholicism was altogether scouted in Madras.

Twenty-five years later, the English troops, after defeating the French in various engagements, captured Pondicherry and demolished its fortifications; and the peace of Paris left the French in India powerless. With the danger of French aggression removed for good, the Company were less intolerant of the religion which Frenchmen professed; and a few years later they paid the Capuchin priests some Rs. 50,000 as compensation for the destruction of the church in White Town and of the chapel in Vepery.