With the publication and circulation of Reuchlin's treatise, and his defense of the Talmud, commenced a struggle which every day became more serious, and at last assumed far greater proportions than the subject justified. For the bigots, still in the full power of their terrorizing might, did not hesitate to take up the challenge. Pfefferkorn's cause was also theirs. Yet a man had dared step forward boldly, not only to disapprove of the condemnation of the Talmud, but also to declare that the persecution of the Jews was unchristianlike; and that they ought, on the contrary, to be treated with sympathy and love. What audacity! It aroused in them such virtuous indignation that they shot beyond the mark, and committed such blunders that they damaged their cause irreparably.

Pastor Peter Meyer, of Frankfort-on-the-Main, who had not been able to obtain the prohibition of the sale of the "Augenspiegel," made the second mistake. He announced from the pulpit during service that Pfefferkorn would preach on the eve of the next "Feast of our Lady" against Reuchlin's Jewish writings, and he exhorted the faithful to attend in great numbers. Nothing could be more fatal than this error. Pfefferkorn with his disagreeable, repulsive face, distinctly Jewish features and coarse, vulgar look, preach before a Christian congregation in his Jewish-German jargon! Each word and each movement would provoke his hearers to laughter, and drive away even sincere devotion. Moreover, was it in accordance with Catholic law that a layman, above all a married layman, should officiate in the church? Not long before this a simple shepherd had been sentenced to be burned on account of unsanctioned preaching. To keep the letter of the law Pfefferkorn preached on the appointed day (September 7th, 1511), not in the church, but before the entrance, to a great crowd of people. It must have been very droll to see how this ill-favored Jew made the sign of the cross over believers, and spoke of the Christian faith in the Jewish jargon. Pfefferkorn's chief desire was to make the Jews and their well-wishers detestable, and to excite the hatred of his hearers against them.

Until now the chief mover of the whole scandal, the venomous and malicious master heretic-hunter, Jacob Hoogstraten, had kept behind the scenes, but had sent his followers to the front one by one: first Pfefferkorn, then Ortuinus Gratius and Arnold von Tongern. Henceforth he stood in the foreground himself, his insolent demeanor seeming to assume that priests and laymen must all bow before him, and sink under his frown in the dust, and that he had the right to tread statutes and customs under his feet. To save, by violent measures, the weakened authority of the order, all Dominicans had to make common cause, and apply their energy to carry through the condemnation of Reuchlin and the Talmud. The conflict spread over a wider area, and became an affair of the whole order.

Authorized by the provincial of his order, Hoogstraten, in his capacity as inquisitor, suddenly issued (September 15th, 1513) a summons to Reuchlin to appear at Mayence within six days, at eight o'clock in the morning, to be examined on the charge of heresy and of favoring the Jews. On the appointed day Hoogstraten, with a host of Dominicans, appeared in Mayence; they were confederates, chosen to sit as judges in the commission. Hoogstraten opened the session, acting at once as judge and accuser. He had prepared an unassailable bill of indictment against Reuchlin and the Talmud, and taken the precaution to seek allies, so that he might not stand alone in this weighty contest. Shortly before, he had addressed letters to four universities, begging them to express their opinion on Reuchlin's book, "Augenspiegel," in accordance with his own views, and all had fulfilled his expectations.

The accusation which he brought forward was, of course, that which Pfefferkorn and Arnold von Tongern had already made. It had for its basis: Reuchlin favors the Jews too much, treats "the insolent people" almost as members of the church, and as men on an equality with others, while his writings savor too much of heresy. Hoogstraten, therefore, instructed the court to pronounce sentence upon Reuchlin's "Augenspiegel": that it was full of heresy and error, too favorable to the unbelieving Jews, and insulting to the church, and therefore ought to be condemned, suppressed, and destroyed by fire. One must not overlook the great difference between a German and a Spanish inquisition court. Torquemada or Ximenes would have made short work of it, and condemned the book together with the author to the stake. Hoogstraten was not too kind-hearted for such a sentence; but he dared not venture so far, because he would have had all Germany, the ecclesiastical as well as the temporal rulers against him.

General indignation was aroused at the injustice of a trial carried on in violation of all rules. The students of the Mayence University, not yet tainted by the corruption of theology, their judgment not warped by casuistry, and not influenced by foreign considerations, loudly proclaimed their displeasure at this shameless proceeding of the Inquisition. They carried the doctors of jurisprudence with them, and this induced other earnest men to interfere.

To the surprise of the Dominicans, the aged, venerable Reuchlin appeared in Mayence, accompanied by two respected counselors of the Duke of Wurtemberg. The chapter now took great trouble to effect a reconciliation. But Hoogstraten, who wished to see smoke rise from the fagots, would agree to nothing, and delayed the negotiations till the 12th of October, the time when the final sentence would be pronounced. The inquisitor commanded all the ecclesiastics in Mayence to announce from the pulpit that everyone, Christian or Jew, if he would escape punishment, must give up all copies of the "Augenspiegel" to the flames. The people were promised thirty days' indulgence, if they assembled on the appointed day at the church square to celebrate the auto-da-fé and increase its splendor. On the 12th of October the place before the church in Mayence was thronged with spectators—the curious, the sympathetic, and the seekers after indulgence! Decked out like peacocks, the Fathers and Brothers of the Dominican order, and the theologians of the universities of Cologne, Louvain, and Erfurt, strutted along to the tribunal erected for them, and "the earth trembled under their feet." Hoogstraten, till now the accuser, again took his place among the judges. They were about to pronounce the formula of the curse, and have the fire kindled, when a messenger hastily arrived, bringing a letter from Archbishop Uriel, which turned them speechless.

Uriel von Gemmingen, like most bishops of his time, was more worldly-minded than spiritual, and had no canonical fanaticism against Jews. The presumptuousness of the Dominicans of Cologne and their unjust proceedings against Reuchlin angered him, too. Therefore, he issued a proclamation to the commissioners selected from his chapter, ordering that judgment be delayed for one month until a new agreement might be arrived at. If they did not consent, this letter deprived them of their privileges as judges of the inquisitorial court, and every thing hitherto decreed was null and void. Utterly dumbfounded, the Dominicans listened to the notary's reading of the document, which entirely frustrated their schemes and machinations. Hoogstraten alone boldly dared express his anger at the denial of their rights. The other confederates slunk away ashamed, followed by the jeers of the street boys, and the cry of the men, "O that these Brothers, who wished to outrage a just man, might be burnt at the stake."

If it is true, as the Dominicans relate, that the rabbis of Germany met in a synod in Worms, and found in the defeat of the Dominicans who raged against Reuchlin a sign of the downfall of the Roman (papist) hierarchy, they were certainly endowed with prophetic vision. It was also said that Reuchlin had secret intercourse with rabbis.

Reuchlin was by no means so situated as to be able to triumph over his enemies and those of the Jews. Though subdued for the moment, they were certainly not vanquished. He knew their cunning and malignity too well to give himself up to inactive enjoyment of his victory. He knew that their persecutions would only be redoubled in the future. Therefore, he hastened to announce his appeal to the pope, so that silence might be imposed from that quarter on his embittered enemies. But Reuchlin justly feared that with the vacillation and venality of the Vatican his cause would go badly, if the investigation were conducted beyond the jurisdiction of the pope by the Dominicans of Cologne. Therefore, he sent a Hebrew letter to Bonet de Lates, the Jewish physician of Pope Leo X, begging him to plead for the pope's favor in his cause.