The territory indeed upon which he intended to settle, was within the province of Anilco, and on the north bank of the Arkansas. The chief Guachoya, very kindly offered to supply De Soto with eighty large and many small canoes with which a portion of his force with the baggage could ascend the Mississippi, twenty-one miles to the mouth of the Arkansas, and then ascending that stream about forty miles would reach the point selected for the settlement. The Governor and the chief, with united military force in light marching order, would proceed by land so as to reach the spot about the same time as the canoes.

Four thousand Indian warriors embarked in these canoes, and in three days accomplished the voyage. At the same time, the land forces commenced their march. The Cacique led two thousand warriors, besides the attendants. Mr. Irving writes:

"The two expeditions arrived safely at the time opposite the village. The chief of Anilco was absent, but the inhabitants of the place made a stand at the pass of the river. Nuño Tobar fell furiously upon them with a party of horse. Eager for the fight, they charged so heedlessly that each trooper found himself surrounded by a band of Indians. The poor savages, however, were so panic-stricken that they turned their backs upon the village, and fled in wild disorder to the forests, amid the shouts of the pursuers, and the shrieks and cries of the women and children.

"On entering the conquered village, they massacred all they met, being chiefly old men, women and children, inflicting the most horrible barbarities.

"In all this they acted in such fury and haste, that the mischief was effected almost before De Soto was aware of it. He put an end to the carnage as speedily as possible, reprimanded the Cacique severely, forbade any one to set fire to a house, or injure an Indian under pain of death, and hastened to leave the village, taking care that the Indian allies should be the first to pass the river, and none remained behind to do mischief."

From this untoward enterprise De Soto returned to the village of Guachoya, renouncing all idea of establishing his colony in Anilco. He immediately commenced with all energy building his two brigantines, while he looked anxiously about in search of some region of fertility and abundance, where his army could repose till the envoys should bring back a sufficient fleet to transport those to Cuba who should wish to return there, and could also bring those reinforcements and supplies essential to the establishment of the colony. The river at this point was about a mile and a half in width. The country on both sides was rich in fertility, and thickly inhabited.

Upon the eastern bank there was a province called Quigualtanqui, of which De Soto heard such glowing reports that he sent an exploring party to examine the country. By fastening four canoes together, he succeeded in transporting the horses across the stream. To his disappointment he found the Cacique deadly hostile. He sent word to De Soto that he would wage a war of utter extermination against him and his people, should they attempt to invade his territories.

Care, fatigue and sorrow now began to show their traces upon the Governor. He could not disguise the deep despondency which oppressed him. His step became feeble, his form emaciate, his countenance haggard. A weary, grief-worn pilgrim, he was in a mood to welcome death, as life presented him nothing more to hope for. A slow fever aggravated by the climate, placed him upon a sick bed. Here, the victim of the most profound melancholy, he was informed that the powerful chief, Quigualtanqui, was forming a league of all the neighboring tribes for the extermination of the Spaniards. De Soto's arm was paralyzed and his heart was broken. He had fought his last battle. His words were few; his despondency oppressed all who approached his bedside. Day after day the malady increased until the fever rose so high, that it was manifest to De Soto, and to all his companions, that his last hour was at hand.

Calmly and with the piety of a devout Catholic, he prepared for death. Luis De Moscoso was appointed his successor in command of the army, and also the successor of whatever authority and titles De Soto might possess, as Governor of Florida. He called together the officers and most prominent soldiers, and with the trembling voice of a dying man administered to them the oath of obedience to Moscoso. He then called to his bedside, in groups of three persons, the cavaliers who had so faithfully followed him through his long and perilous adventures, and took an affectionate leave of them. The common soldiers were then, in groups of about twenty, brought into the death chamber, and tenderly he bade them adieu.