The fumes of various narcotic plants are inhaled by eastern nations at present, for smoking in the east is an entirely different process from smoking in the west of Europe, where the fumes of tobacco are merely drawn into the mouth and then puffed out again. In Asia and some of the eastern parts of Europe, the fumes of opium, tobacco, datura, Indian hemp, or whatever else is smoked, are always inhaled into the lungs.
John Baptista Porta of Naples makes the following statement in his work on Natural Magic,[[24]] published in 1597:—
“At last shall be related a wonderful method by which any sleeping person may inhale a soporific medicine. From what we have said, any one will easily know that he is liable to suffer severely after sleep caused by medicine, and to have his suspicions aroused.
“But the quintessence is extracted from a number of the above named medicines by somniferous menstrua. This is put into leaden vessels perfectly closed, lest the least aura should escape, for the medicine would vanish away. When it is used, the cover being removed, it is applied to the nostrils of the sleeping person, he draws in the most subtile power of the vapour by smellings, and so blocks up the fortress of the senses that he is plunged into the most profound sleep, and cannot be roused without the greatest effort. After the sleep, no heaviness of the head remains, nor any suspicion of trick or fraud. These things are plain to the skilful physician, but unintelligible to the wicked.”
The author does not make known what the “somniferis menstruis” were, with which the “quinta essentia” were extracted. As sulphuric ether had been described more than fifty years before he published his work, it is not improbable that this was the evanescent substance which required to be so carefully closed up, and that the profound sleep was simply caused by this, as the narcotic principles dissolved in it would remain in the bottle in the form of extracts. The benefit of inhalation has been frequently attributed to medicines which were supposed to be inhaled, when it was really due to the menstruum in which the medicines were dissolved. This often happens at present when the menstruum is merely water. Baptista Porta does not say that operations were performed under the influence of the inhalation, or, in fact, that it was applied to any useful purpose whatever.
The Persian Pharmacopœia[[25]] contains some recipes for fumigation, called bouc-houri, that were inhaled, for the medicines are directed to be made up into balls or cubes which are to be placed on the live coals, and the head is to be held over them. Some of the prescriptions contain myrrh, camphor, mace, and storax, and are for the cure of coryza and catarrh; one containing musk, camphor, guaiacum, etc., is said to comfort the brain and intellect, and to be useful in palpitation of the heart, faintness, and debility of the senses. This Pharmacopœia also contains[[26]] a “remedium odorativum somniferum”, which consists of opium and camphor, besides the seeds of roses and the root of mandragora. The ingredients are to be powdered and put in a box, for the purpose of being smelt at. There is also[[27]] a stupifying remedy prepared with five drachms of opium and ten drachms of black poppy, which are directed to be boiled to dryness in water with a pound of wheat, and then powdered. It is added that whoever shall take a drachm and a half of this wheat will be alienated from his senses. With regard to the last but one of the above prescriptions—that to be put in a box for smelling, it may be observed that, as heat was not applied, the only ingredient which would produce any effect is the camphor.
The discoveries of Cavendish, Priestley, Lavoisier, and others respecting the nature of atmospheric air and the more important gases, gave an impetus to medicinal inhalations, at the latter part of the last century. Dr. Beddoes, in particular, distinguished himself by the administration of oxygen, hydrogen, carbonic acid, and other gases, in consumption and various diseases. Dr. Richard Pearson exhibited the vapour of ether in consumption with some advantage in the year 1795.[[28]] Three years afterwards, a medical pneumatic institution was established at Bristol, by the exertions of Dr. Beddoes and others. The celebrated Humphrey Davy was the superintendent. This establishment was not very successful in the immediate objects for which it was instituted, but Davy made at this place his masterly researches concerning nitrous oxide gas. In the course of his experiments, he found that severe pain arising from inflammation of his gums was relieved by breathing this gas, and he published the following opinion:—
“As nitrous oxide in its extensive operation seems capable of destroying physical pain, it may probably be used with advantage during surgical operations in which no great effusion of blood takes place.”[[29]]
This suggestion of Sir Humphrey Davy was not acted on either by himself or any other person for nearly half a century, when the late Mr. Horace Wells, Surgeon Dentist of Hartford, Connecticut, having witnessed the exhibition of nitrous oxide gas by a public lecturer, named G. Q. Colston, was induced, in consequence of what he saw of its effects, to request Mr. Colston to accompany him to his office and exhibit the gas to him, whilst another dentist, named Dr. Riggs, extracted a tooth for him which was troublesome. The tooth was extracted without pain, and Mr. Wells, after the effect of the gas had subsided, exclaimed, “A new era in tooth pulling.” This took place on December 11th, 1844.[[30]] Mr. Wells administered the nitrous oxide in thirteen or fourteen cases of tooth-drawing in Hartford with a success more or less complete, and before the end of the year he repaired to Boston to introduce his discovery to the professors at the Massachusetts General Hospital. He called on Drs. Warren and Hayward, who invited him to exhibit the gas to one of the patients, who was expecting to have a limb amputated. He remained two or three days in Boston, but the patient decided not to have the operation performed at that time. The nitrous oxide was consequently tried on an individual who required to have a tooth extracted. This patient felt some pain, and the application was considered to be a failure. It is worthy of remark that Drs. Charles T. Jackson, and W. T. G. Morton, were present on this occasion. Mr. Wells returned to Hartford in disappointment. He expressed his opinion to his friends that the nitrous oxide gas was uncertain in its action, and not to be relied on; and he altogether abandoned the use of it until some time after Dr. Morton’s discovery of the effects of sulphuric ether in preventing pain.
As long ago as 1818 an article, which is believed to have been written by Mr. Faraday, appeared in the Quarterly Journal of Science and Arts,[[31]] describing the great resemblance between the effects of the vapour of ether and nitrous oxide gas. This circumstance has since been published in all the standard works on chemistry; and it was the annual custom of the late Professor Turner, of University College, London, to pour a little ether into a bladder of air, and allow some of the students to inhale the vapour. The same practice prevailed, more or less, in other colleges, both in Europe and America, when the lecture on ether was delivered. The resemblance between the action of nitrous oxide and that of vapour of ether was therefore extensively known.