Dr. Morton, surgeon dentist of Boston, in America, administered sulphuric ether, by inhalation, to a man in his office, on the 30th of September, 1846, and extracted a tooth without causing any pain. He applied the ether in several cases of a similar kind during the next few days. Having obtained the permission of Dr. J. C. Warren, he administered it to a patient in the Massachusetts General Hospital, on whom that surgeon performed an operation on the neck. On the following day, Dr. Morton exhibited ether to a woman in the same hospital, whilst Dr. Hayward removed a large fatty tumour from the arm, and after this date it was frequently administered.
Dr. Morton was well acquainted with Mr. Horace Wells, before alluded to, and had been in partnership with him. Before administering the ether to his patient in September 30th, Dr. Morton had a conversation with Dr. Charles J. Jackson, Professor of Chemistry, respecting the safety and propriety of the application, and the names of these gentlemen were associated in a patent which they took out for the discovery. Dr. Jackson asserts that Dr. Morton knew nothing of the effects of the vapour of ether till he gave him the information; whilst the latter says it was his intention to use the ether before he went into Dr. Jackson’s laboratory. It seems impossible to arrive at the exact truth on this point, but it is admitted on all hands, that Morton was the first who administered ether to prevent the pain of an operation. Dr. Jackson[[32]] has indeed claimed the whole merit of the discovery, on the ground of the alleged information he gave to Dr. Morton; but, if every word Dr. Jackson says be admitted, it only appears that he suggested the use of ether to Dr. Morton, just as Sir Humphrey Davy had suggested the use of nitrous oxide to all the world in the year 1800. Dr. Jackson had inhaled ether as hundreds of others had done, and being aware of Davy’s suggestion of nitrous oxide for preventing the pain of operations, he concluded that ether might also have that effect.
It will be shown further on that Mr. Waldie, of Liverpool, had a greater share in the introduction of chloroform than Dr. Jackson had in the introduction of ether—even supposing that Dr. Morton was previously quite ignorant of that medicine; for when he informed Dr. Simpson of the existence and nature of chloroform, he was able to give him, not merely an opinion, but an almost certain knowledge of its effects; yet Dr. Simpson is justly considered to be the person who discovered and introduced the use of undiluted chloroform as a substitute for ether.
The practice of the ancients in giving mandragora and Indian hemp has no connection with the recent discovery for preventing the pain of operations, which may be briefly related as follows:—Sir Humphrey Davy made the suggestion that nitrous oxide gas might be employed for this purpose, and, at the end of forty-four years, Mr. Horace Wells carried this suggestion into practice, but failed to bring the nitrous oxide into general use, and gave the matter up. Two years later, Dr. Morton, who was well acquainted with the efforts of Mr. Wells, applied the vapour of ether, which was already known to resemble nitrous oxide in its action. He succeeded completely in preventing the pain of operations, and in bringing his discovery into general use throughout the civilized world. In a short time the inhalation of ether was found to be so safe and certain in its action, and to prevent the pain of operations so entirely, that the most ardent imagination could scarcely conceive that anything further could be desired in this direction.
Dr. Morton withheld at first the name of the agent he was employing, but its strong and peculiar odour revealed it so plainly that concealment was impossible. Dr. Bigelow, of Boston, having tried sulphuric ether, and found it to produce all the effects of the so-called letheon, he made the subject known, not only to his own countrymen, but also by letter to Dr. Boot of London. The first operation under the influence of ether on this side of the Atlantic, was the extraction of a tooth, at the house of Dr. Boot, on Dec. 19th, 1846. Mr. Robinson, of Gower Street, administered the ether and performed the operation. The patient was a lady, named Miss Lonsdale. The ether was quite successful in preventing the pain in this case, as well as in two operations performed at University College two days afterwards, by the late Mr. Liston. These operations were amputation of the thigh, and evulsion on both sides of the great toe-nail. The ether was given by Mr. Squire, of Oxford Street, with an apparatus which he contrived for the occasion.
Considerable opposition was made to the inhalation of ether in America, soon after its introduction, and it seemed likely to fall into disuse, when the news of its successful employment in the operations of Mr. Liston, and others in London, caused the practice of etherization to revive. Mr. Robinson, dentist, gave much time and attention to the exhibition of ether in London on its first introduction, and was on the whole very successful. This was not generally the case, however, with other operators during the first six weeks of the new practice. Owing to imperfections in the inhalers employed and in the method of using them, the ether often either failed altogether or only made the patient partly insensible; and Mr. Liston, and some other surgeons, were inclined to discountenance the use of it, in consequence of the struggles and cries of patients to whom it had been administered.
It soon became apparent, however, that the vapour of ether was capable of inducing a state of perfect quietude, with entire absence of pain, during all kinds of surgical operations. From the 28th of January the ether produced the desired effect in every operation that was performed in St. George’s Hospital, until the time when chloroform was introduced as a substitute for this agent.[[33]]
Ether was employed in Paris a few days after its first application in London, and in a short time it was in use nearly all over the world.
On the 19th of January 1847, just a month after the first application of ether for the prevention of pain on this side of the Atlantic, Dr. Simpson of Edinburgh administered the vapour in a case of labour, and ascertained that it was capable of removing the sufferings of the patient without interfering with the process of parturition. Etherization was soon afterwards employed in the reduction of strangulated hernia and dislocations of the femur and humerus, some of them of long standing. It was also used with advantage in neuralgia, tetanus, and the convulsions of infants, and it became more and more general in surgical operations.
No great improvement in the practice of medicine was probably ever established so readily as the inhalation of ether for the prevention of pain. Yet it met with stout opposition in certain quarters, and when a serious operation in which ether had been used terminated unfavourably, there were those who attributed the patient’s death to the new practice, although numerous other patients had sunk in exactly the same manner long before ether was used. In one of these cases a coroner’s inquest was held, and the jury returned a verdict that the death of the deceased was caused by the inhalation of ether, although the patient had not even been made insensible by it, had felt all the pain of the operation, which was retarded by her struggles, and did not die till the third day. Notwithstanding a certain amount of opposition and mistrust, the inhalation of ether was becoming more general in the course of the year 1847, and there is every reason to conclude that it would very soon have obtained the complete confidence of the medical profession and the public, had it not been for circumstances which must next be considered.