Further particulars are not given; but as the patient died suddenly, when the surgeon had scarcely divided the skin, it must be admitted that he was, in all probability, correct in attributing the event to the chloroform. The patient usually yields to the laws of gravity when only partially under the influence of chloroform, and it seems surprising that the operation should have been undertaken without placing the patient in the horizontal posture. The proper position of the patient, when a large tumour of the back is to be removed, is to be lying almost flat on the abdomen, the head being a little turned on one side, so that it rests with one ear on the pillow.
Case 37. Jane Morgan, aged fifty-nine, died whilst inhaling chloroform in the Bristol Infirmary, on January 21st, 1854. She was moderately stout, pale, but not otherwise of unhealthy appearance. “The stethoscopic indications were favourable, the beat of the heart was natural, and the air passed freely throughout both lungs; but the chest movements on the right side were not quite so free as on the left.” Chloroform was ordered by Mr. Harrison, the senior surgeon of the Infirmary, with the intention of attempting to reduce a dislocation of the humerus of eight weeks standing. “Having taken no food since her breakfast, she commenced the inhalation of one drachm of chloroform, at 2 P.M., in bed in her ward, under the superintendence of Mr. Hore, the house-surgeon. Nothing unusual occurring in the patient’s general condition during inhalation, a second drachm, in about five minutes from the first, was poured upon the sponge, and the inhalation was continued. Almost immediately after the addition of the second drachm, the chloroform was withdrawn, as the patient’s breathing became stertorous; and immediately afterwards her pulse, which had hitherto continued pretty firm, was suddenly imperceptible, the respiration ceasing at the same time. The pupils were not dilated.” Various measures were promptly resorted to with the hope of restoring the patient; but there were no further signs of life, unless “some convulsive efforts of the respiratory muscles,” under the application of galvanism, be so regarded.
At the examination of the body on the following day, the right pleura was found to be adherent. The lungs were healthy in structure, but gorged with dark fluid blood. There was about an ounce of fluid in the pericardium. There was a small quantity of fluid blood in each of the cavities of the heart. For the length of an inch from their commencement, both coronary arteries were much dilated, and studded with atheromatous and bony deposits. The muscular structure of the heart was examined under the microscope by Dr. William Budd, and a considerable proportion of the fibres were found in a state of incipient fatty degeneration. It was learned, after her death, that she had been subject to occasional attacks of fainting.[[108]]
Case 38. A death from chloroform occurred in the Hôpital St. Antoine, at Paris, in the spring of 1854. The subject of this was a woman aged forty, on whom M. Richard was operating for the removal of a uterine polypus. The surgeon placed the patient in the horizontal posture, and administered the chloroform on a compress of lint. She became insensible in two minutes, having first been excited so that it was necessary to hold her. M. Richard moved the patient to the edge of the bed, gave the compress containing the chloroform into the hands of an assistant, and commenced the operation, which was likely to be of short duration. He had almost completed it, when he was apprised by an assistant, who had been set to feel the pulse, that it had ceased to beat. He sought for it himself, but found that it did not beat. The face was extremely pale; a slow respiration still continued, but soon ceased; and the measures which were used with the hope of restoring the patient were of no avail.[[109]]
At the examination of the body all the organs were found in a healthy state. The right cavities of the heart and the great veins contained a considerable quantity of blood, and the left cavities of the heart a small quantity. The blood was everywhere fluid.[[110]]
Case 39. A patient, named Mrs. Harrup, died at Sheffield from the effects of chloroform administered with the intention of removing a cancerous tumour of the left breast. The age of the patient was forty-five, and she was stated to be in good health, excepting the local affection.
“The chloroform was administered with more than the usual precautions. After the inhalation had gone on without any effect for twenty minutes, it was thought that possibly different chloroform might succeed, and one ounce was accordingly procured from the public dispensary. After the inhalation had been conducted with the fresh chloroform about twenty minutes, the usual effects of the vapour began to manifest themselves. The pulse, which was 136 before any chloroform had been given, and had been very gradually decreasing in frequency while it improved in strength, was now about 104. At this moment muttering—half articulate delirium—came on, but ceased in a few moments, and was immediately followed by conclusive signs of the satisfactory action of the chloroform. Dr. Law now desired Mr. Wright to begin the operation; but before he could do so, Dr. Law, seeing an alarming change in the countenance of the deceased, cried, ‘Stop, Mr. Lewis, how is the pulse?’ I replied, ‘It is gone.’” After stating the means which were used with a view to resuscitate the patient, it is added that the heart had ceased to beat, and that, after a few short and laboured inspirations, life became extinct.
At the examination of the body, the cartilages of the ribs were found to be ossified. The heart and lungs were perfectly healthy, but the lungs were in a congested condition. There was an extravasation of blood in the spinal muscles, and a little blood in the spinal canal, in what part or between what structures is not stated.[[111]]
Case 40 occurred in the Lock Hospital, London, in May 1854. Walter Hollis, a tailor, aged eighteen, had been under treatment for sores within the prepuce, and these having healed, he was about to undergo the operation for congenital phymosis. He had been of dissolute habits, and exhibited a pale cachectic appearance.
“The inhaler used was a simple mouth-piece by which the nostrils are left uncovered. About two drachms of the fluid were poured into the instrument. After about six minutes inhalation, insensibility seemed to be coming on, and at this moment the pulse was ascertained to be of good volume. Nothing whatever had occurred to indicate the impending danger, when, after a few more inhalations, the pulse suddenly failed, became quite imperceptible, and the countenance assumed a pale and leaden hue. The inhalation was immediately stopped, and attempts to resuscitate, by means of striking the chest sharply with a wet towel, applying ammonia to the nostrils, and by artificial respiration, were at once commenced. These were employed for three or four minutes before any signs of life were perceived; but, subsequently, the pulse was again to be felt, and spontaneous respiration was renewed. Artificial respiration was desisted from on the occurrence of these signs of returning life, and for upwards of ten minutes the chest continued to fill regularly, and the pulse beat at a rate of from 40 to 50 in the minute; the countenance of the patient also much improved, and even assumed a slight flush. After the expiration of, perhaps, a little more than ten minutes, however, these indications of returning vitality again disappeared, the pulse and respiratory efforts simultaneously ceased, and the countenance became deathlike. Artificial respiration and the other means were again adopted, but this time without the slightest success.... Post-mortem examination on the next day shewed great venous congestion within the cranium; the lungs were also somewhat congested. The heart was slightly enlarged, and the ventricular parietes were thinned; in the muscular fibres the microscope detected decided fatty degeneration. The blood was universally fluid.”[[112]]