“For three or four minutes nothing unusual presented itself; the pulse and respiration proceeded normally. There was put on the lint, at first, one fluid drachm of chloroform; and, at the end of three or four minutes, forty minims more were added. This was the whole quantity of chloroform employed. Within a minute after the second quantity of chloroform was added, the patient struggled violently both with her arms and legs. During these struggles I was holding her right hand, and was unable to feel the pulse in consequence of her constant motions. The struggling lasted about a minute, and on its ceasing, the patient commenced to breathe with loud, rough stertor. I at once removed the lint from before the face, and felt for the pulse, which I could not find. Immediately cold water was dashed on her face. She breathed with this stertor for two or three short inspirations, and then two or three long ones, and then the breathing ceased. Immediately artificial respiration was resorted to, and within a minute galvanism was applied to the back of her neck and the diaphragm. Under the influence of these agencies, the patient gasped about three times at intervals; after this, no further signs of life were exhibited.
“At the time when the stertor commenced and the pulse failed, the pupils were dilated, and the face of the patient was only slightly altered. The tongue was not retracted, for one of the bystanders at once put his fingers into her mouth to ascertain this.”
At the autopsy made by Dr. Garrod thirteen hours after death, the rigor mortis was well marked; the blood was very fluid in all parts of the body. There was about an ounce of colourless fluid in the pericardium. The heart was quite collapsed and empty, but, as Dr. Garrod observes, this may have been due to the fluidity of the blood. The weight of the heart was seven ounces and three-quarters; valves healthy. Walls of the right ventricle flabby and pale; mean thickness one eighth of an inch. At some parts the muscular substance was in a very thin layer, being much encroached on by fat. In several places there was scarcely any muscular fibre visible. This was chiefly the case near the apex. Examined by the microscope, much fatty degeneration of the muscular fibres of the right ventricle generally was discovered. The walls of the left ventricle were flabby, dry in appearance, pale, and very friable. Both lungs were crepitant throughout, not much engorged. Brain not congested. The intestines above the strangulation were much distended with flatus, and inflamed.[[103]]
Case 34 occurred on October 20th, 1853, a few days after the last. The patient was a young woman named Ann Smith, aged 22 years, under the care of Mr. Paget in St. Bartholomew’s Hospital, who was about to apply the actual cautery to a sore of cancroid nature in the vagina. She was a stout, florid young woman, formerly of dissolute habits, but apparently in perfect health, with the exception of the local ailment. She had been put under the full and prolonged influence of chloroform a fortnight previously for the application of the cautery, without the occurrence of any untoward symptoms whatever. The chloroform was administered by Dr. Black, one of the assistant physicians.
“The usual form of inhaler was employed,—a padded metal cup, fitting over the nose and mouth, and supplied with valves. A drachm, by measure, was first poured on the sponge, but as the administration did not immediately commence, a considerable part of this was no doubt wasted; after a short inhalation, a second drachm was supplied, and subsequently the further quantity of half a drachm. The patient had gone through the usual stages of excitement, etc., and the last dose was scarcely used, as she sank off, almost immediately after its application, into a state of complete insensibility, unattended by any alarming symptoms. About five minutes had been occupied by the inhalation, and probably not more than a drachm and a half of the fluid really inhaled. The apparatus was now removed from the face, and the patient having been drawn into the proper position, Mr. Paget was about to commence the operation, when Dr. Black, who throughout had kept his finger on the pulse, noticed it to have become extremely weak and fluttering. Almost immediately afterwards, the patient’s countenance was observed to be dusky, turgid, and congested, and the respiratory movements began to be performed at long intervals, and by slight catching efforts. No time was lost; cold water was at once dashed on the thighs, face, and breast; and, the failure of the respiration becoming shortly complete, Mr. Paget immediately began artificial insufflation of the lungs, by alternately blowing into the nostrils, and compressing the chest. Just before commencing this process, Mr. Paget had ascertained, by drawing the tongue forwards and examining the glottis with the finger, that the epiglottis was not pressed down.”
Other means were employed, but no further signs of life appeared. It is further recorded that, “immediately after the first alarming symptoms, the pupils were of the medium size, neither contracted nor dilated. All efforts at respiration ceased about two minutes after the first indications of failure; the pulse, however, as a very feeble flutter, was felt occasionally for at least two minutes later.”[[104]]
At the autopsy, performed by Mr. Paget, twenty-two hours after death, “the thorax was first examined, and nothing whatever abnormal could be detected in any of the viscera; the lungs were healthy and crepitant in every part; their posterior lobes were not more congested than is seen in almost every examination; the heart, collapsed, but not contracted, and containing a small quantity of fluid blood in each cavity, was of normal size and proportions, in every respect, and its muscular structure, examined by the microscope, showed no degeneration.... The brain, its sinuses, ventricles, etc., were all carefully examined, and neither in texture nor quantity of blood was anything abnormal detected.”[[105]]
Although the failure of the pulse was the first symptom of danger in this case, it continued to be felt as a very feeble flutter for about four minutes, so that the heart was not so completely paralysed as in most of the fatal cases. It must, however, have been so far paralysed as to be past recovery.
Case 35. Professor Dumreicher related a case of death from chloroform at the meeting of the Vienna Society of Physicians, held on November 16, 1853. The patient was a young man, aged nineteen, in somewhat feeble health, who inhaled chloroform in the recumbent position, in order to have his anchylosed knee-joint forcibly extended. It was inhaled from a vessel resembling a snuff-box, which was held to the nostrils. “The inhalation was continued for fifty seconds, and the patient had spoken a few seconds previously, when Professor D. observed that the pulse had become frequent and undulating. He immediately suspended the administration of the anæsthetic. Trismus occurred; the respirations became irregular; the face turned livid, and he foamed at the mouth.” The measures which were employed included the abstraction of eight ounces of blood from the jugular vein, but they were of no avail. He only once made a feeble attempt at inspiration.[[106]]
Case 36 occurred in the practice of Dr. Wüstefeldt of Neustedt. “A young girl, thirteen years of age, had on the dorsal region a voluminous lipoma, which extended from the last dorsal vertebra to the crest of the ilium.... One drachm of chloroform was employed. As soon as insensibility was manifested, the operation was commenced, but scarcely had the surgeon divided the skin, when the girl, yielding to the laws of gravity, fell suddenly forwards on her chest. Dr. Wüstefeldt, struck by the phenomenon, which he had witnessed before under similar circumstances, immediately desisted from operating, and strove to restore the patient to life; but every effort was useless, and, in the course of a few minutes, it became evident that she was dead.”[[107]]