After the lapse of seven hours, the animal appeared dejected; he refused to eat or drink; the extremities were cold; breathing 16 in the minute; pulse 60, small and irregular.
February 27th. The vein can be felt thickened as far as the sternum. The general symptoms are the same as on the previous evening.
28th. There appears less constitutional irritation; pulse 60; respiration 14.
March 2nd. Appetite still indifferent; pulse 60; respiration 16.
From this date to the 7th, when the animal was destroyed, the general symptoms continued much the same, but the induration and swelling around the jugular vein, from the opening to the sternum, became greater.
Post-mortem appearances. The left jugular vein was found completely obliterated. The remains of a firm coagulum obstructed its canal for some distance below the opening which had been made into it, and terminated, below, in an elongated conical portion, which adhered to one side only of the vessel. On the right side, an abscess had formed in the course of the vein; and for two inches, the whole of the parts were imbedded in a confused mass of pus and lymph, in which it was impossible to distinguish the structure of the vein. Both above and below this, for several inches, the vein was filled with coagula, which effectually obliterated it. These coagula extended for several inches in the course of the circulation; but beyond them, in both directions, the vessel was pervious. The lungs presented some slight spots of congestion, but not of the same characteristic kind observed in Experiment vi. The other organs were healthy.
EXPERIMENT IX.[27]
Two drachms of pus, somewhat fetid, derived from a large common ulcer, and diluted with a little water, were injected into the jugular vein of a middling-sized dog. The animal immediately made several convulsive efforts to swallow, and soon became faint. It showed indications of pain, and vomited more than six times in the course of the day. At the expiration of an hour, it appeared slightly relieved by an evacuation, and by passing turbid urine. In the evening, it was very ill; it lay upon its side with its legs extended; had a very feeble pulse and scarcely perceptible respiration. Ten hours after the experiment, it passed black, liquid, and extremely offensive motions; these were accompanied by immediate relief. The animal regained its appetite, eat and drank freely, and went to sleep. The day following, it appeared nearly well. On the third day, three drachms of the same pus were injected into the opposite vein; after the lapse of a certain time, there occurred, as in the first instance, faintness, vomiting, and frequent desire to pass urine; twelve hours after the injection, frequent liquid, white, and very fetid motions were passed, and the animal died at the expiration of twenty-four hours. On opening the body, no alteration was found either in the intestines or other organs.
The last experiment was repeated on a greyhound with the same results: faintness, fever, vomiting, and repeated evacuations succeeded each other, with recovery after the first experiment, but not after the second. On opening the body, no lesion was observed, except that the inferior lobes of the lungs were gorged and almost hepatized.