Three drachms of recent pus, derived from the same patient as in the last experiments, were injected into the jugular vein of a small emaciated unhealthy dog. After the expiration of three minutes, there was an abundant evacuation of urine, followed by continued vomiting, and repeated ineffectual efforts to pass fæces. For nearly a quarter of an hour, there was a kind of emprosthotonos, rigidity of the limbs, and a death-like condition. Subsequently, fresh vomiting ensued, with very fetid liquid evacuations, which were followed by apparent relief; soon after, however, long continued tenesmus made its appearance, and terminated in death, five hours after the injection of the pus. On opening the body, the mucous membrane of the intestines was found red, swollen, and inflamed, especially in the colon and rectum.
Half an ounce of pus, similar to that used in the preceding instances, but more putrid, in consequence of having been longer kept, was introduced into the veins of a middling sized dog. The animal, as in the other cases, was seized with vomiting, accompanied by violent straining. Subsequently, strongly marked nervous symptoms made their appearance. The eyes wandered; there was extreme sensibility, and involuntary convulsive twitching over the whole body, accompanied by faintness, hiccough, and short piteous cries. The walk was unsteady, staggering, and without apparent object. There was furious delirium, ardent thirst, dyspnœa, palpitation of the heart, etc. This state lasted for nearly two hours, and the animal died in frightful convulsions, without having experienced any critical evacuations, as in the former cases.
Post-mortem appearances. On opening the body, while still warm, the venous blood was found very firmly coagulated, not parting with any of its serum when left at rest; the left ventricle of the heart showed, on its external surface, some stains of the colour of lees of wine, formed by a kind of concrete pellicle, which disappeared only after long rubbing and maceration. The other organs appeared healthy.
Some beef was allowed to decompose in some dog's blood; half an ounce of the fluid resulting from the decomposition, was injected into the jugular vein of a little bitch. Immediately, the animal made several convulsive efforts to swallow, and soon became oppressed, uneasy, and faint. At the expiration of an hour, there was great prostration, accompanied by repeated gelatinous and bloody evacuations, and vomiting of bilious matter. The strength became gradually less, and the animal died three hours after the injection.
Post-mortem appearances. The lungs were found inflamed in a very peculiar manner. They were gorged with blood, of a violet or black colour, and presented many petechial spots, like small ecchymoses. These spots existed also on the left ventricle of the heart, in the spleen, in the mesenteric glands, in the gall-bladder, and even in the subcutaneous cellular tissue. The peritoneum contained some spoonsful of a reddish serum; but the mucous membrane of the digestive organs was found to have been principally affected. In the stomach it was slightly inflamed. In the intestines, but especially in the duodenum and rectum, it was of a livid colour, presenting many black spots, and covered by a gelatinous and bloody secretion, resembling lees of wine. The tissues in these parts were slightly thickened.