In 1422 the church became collegiate, when Henry V. granted a charter to Thomas, Lord de la Warre, Rector of Manchester, and Lord of the Manor "Ecclesiam de Mancestre in ecclesiam collegeatam erigere," and from this date the title of Rector was exchanged for that of Warden.
The following is a complete list of the wardens, with the dates of their appointments:—
1422. John Huntington, B.D. (rector of Ashton-under-Lyne); he is noteworthy as the builder of much of the church which we see to-day.
1459. John Booth, LL.B., archdeacon of Redmore, formerly treasurer of the cathedral church at York.
1465. Ralph Langley, LL.D., rector of Prestwich, the rebuilder of the nave.
1481. James Stanley (1), D.D., Prebendary of St Paul's and archdeacon of Chester.
1485. James Stanley (2), M.A., D.C.L. He founded the Chapel of St. John the Baptist, built the entrance to the chapter house, and in connection with Richard Beck, a Manchester merchant, erected the choir stalls and canopies. He became Bishop of Ely in 1509, and is buried in the Ely Chantry at Manchester.
1509. Robert Cliff, B.D., LL.D.
1515. Richard Alday.
1518. George West.