We learn from the same old newspaper that Doctor Caldwell was announced to deliver a lecture, a few evenings later, at the first meeting of the "Lexington Lyceum," at the court house. The subject of the lecture was "The Moral and Incidental Influences of Railroads." "Ladies and strangers" were invited to attend.

But in later days, in competition with the steamboat, the newer and swifter mode of transportation—the railroad—has been gradually but surely restoring to the inland regions, and to Lexington, their lost prosperity. Our city has steadily risen to about seventeen thousand (1873), with a good prospect of a further increase of prosperity and population as railroads centering here may be extended. Then may we hope to put into active operation once more our time-honored Medical College, and to attract to it a creditable number of students. More particularly if, with the co-operation of the more enlightened members of our profession, an effort be faithfully made in the renovated college to bring about the much-needed reform in medical education, the necessity for which is now generally recognized. So that the mere fact of a student attending two courses of lectures, with other somewhat easy requisitions, may not entitle him to the degree of Doctor of Medicine, as has been too frequently the case amongst competing medical colleges. That full preparation and training, in a sufficient period of time, shall be required of the candidates into whose hands the health and lives of communities are to be committed. On such a basis—when our city may have acquired increased facilities for clinical instruction, and when anatomical studies will not be cramped for want of means of demonstration—the old Medical College of Transylvania may revive under the wing of a people's educational institution such as Transylvania is and always was—a "State University."

Difficulties in the procurement of a sufficient supply of material for anatomical instruction, coupled with the demand for clinical teaching which was beginning to be urged by the profession, forced themselves on the attention of the Medical Faculty of Transylvania before the year 1836–37. But in that year a determined effort was made, engineered and led by Professor Caldwell, to remove the Medical College to Louisville, that city having been induced by the earnest and eloquent appeals of Caldwell to offer it a large bonus. But for the early withdrawal of Doctor Dudley from this promising scheme, toward which he was at first inclined—because mainly of his difficulties in the supply of anatomical material—it would have been successful. But Doctor Dudley finally declined to remove, much to the mortification of Doctor Caldwell, who, in his last valedictory to the graduates of 1837, indulged in a very bitter impersonal-personal tirade against deception and mendacity, aimed at Doctor Dudley—not saying openly to his colleague "thou art the man"—but hoping "the cap would fit him" and find its place. The Trustees of the University, of course, and influential citizens, violently opposed the proposed change. Doctor Caldwell was arraigned before the Board on charges preferred by Doctor Dudley, the principal of which was that he had been engaged in the enterprise of originating a rival medical college in Louisville while he was yet a professor in the Transylvania College and under oath to support it. Doctor Caldwell, disdaining to answer the summons of the Board, was, after a long and full investigation of the evidence, dismissed from his chair in Transylvania. The Medical Faculty was then dissolved and reorganized.[48]

Doctors Cooke and Yandell, and finally Doctor Short, joined Doctor Caldwell to aid in the establishment of the Louisville Medical Institute. Professors Dudley and Richardson and the assistant professors, Bush and Peter, remained in Lexington. The celebrated Professor John Eberle was called to the chair of Theory and Practice, but he died shortly after the delivery of his introductory lecture. Professor Thomas D. Mitchell was appointed to the chair of Chemistry, etc., and Doctor James C. Cross to that of the Institutes of Medicine.[49]


Doctor John Esten Cooke

Removed from Virginia in 1827 to fill the chair of the Theory and Practice of Medicine in Transylvania University, which had just been vacated by Doctor Drake. He had already acquired a high reputation as a practitioner of medicine; he had published an able essay on autumnal fever in the Medical Recorder for 1824, and had in the same year produced the first volume of his very remarkable Treatise on Pathology and Therapeutics, the second volume of which he published in Lexington in 1828. The promised third volume, which was to complete the work, never appeared. He remained in Transylvania Medical School until 1837, when, under the leadership of Doctor Caldwell, he with Doctor Yandell, removed to Louisville to engage in originating a new medical college, the "Louisville Medical Institute." In this and in its successor, the "Medical Department of the Louisville University," he remained until a few years before his death, which occurred on his farm on the Ohio River above Louisville, October 19, 1853, in the seventy-first year of his age.