As all diseases proceeded in his opinion from the archeus, the object of his treatment was to calm the archeus, to stimulate it, and to regulate its movements. To accomplish these objects he relied upon dietetics, and upon acting on the imaginations of his patients. He considered certain words as very efficacious in curing the diseases of the archeus. He admitted the existence of the universal medicine, to which he gave the names of liquor alkahest, ens primum salium, primus metallus. Mercurials, antimonials, opium, and wine, are particularly agreeable to the archeus, when in a state of delirium from fever.
Among the mercurial preparations, he praises what he calls mercurius diaphoreticus as the best. He gives no account of the mode of preparing it; but from some circumstances I think it must have been calomel. He considers it as a sovereign remedy in fevers, dropsies, diseases of the liver, and ulcers of the lungs. He employed the red oxide of mercury as an external application to ulcers. The principal antimonial preparations which he employed were the hydrosulphuret, or golden sulphur, and the deutoxide, or antimonium diaphoreticum. This last medicine was used in scruple doses—a proof of its great inertness compared with the protoxide of antimony.
Opium he considered as a fortifying and calming medicine. It contains an acrid salt and a bitter oil, which give it the virtue of putting a stop to the errors of the archeus, when it was sending its acid ferment into other acid parts of the body. Van Helmont assures us that he wrought many important cures by the employment of wine.
Such is a very short statement of the opinions of a man, who, notwithstanding his attachment to the fanatical opinions which distinguished the time in which he lived, had the merit of overturning a vast number of errors, both theoretical and practical; and of laying down many principles, which, for want of erudition, have been frequently assigned to modern writers. Van Helmont has been frequently placed on the same level with Paracelsus, and treated like him with contempt. But his claims upon the medical world are much higher, and his merits infinitely greater. His notions, it is true, were fanatical; but his erudition was great, his understanding excellent, and his industry indefatigable. His writings did not become known till rather a late period; for, with the exception of a single tract, they were not published till 1648, by his son, after his death.
The decided preference given to chemical medicines by Van Helmont, and the uses to which he applies chemical theory, had a natural tendency to raise chemistry to a higher rank in the eyes of medical men than it had yet reached. But the man to whom the credit of founding the iatro-chemical sect is due, is Francis de le Boé Sylvius, who was born in the year 1614. While a practitioner of medicine at Amsterdam, he studied with profound attention the system of Van Helmont, and the rival and much more popular theory of Descartes: upon these he founded his own theory, which, in reality, contains little entitled to the name of original, notwithstanding the tone in which he speaks of it, and his repeated declarations that he had borrowed from no one. He was appointed professor of the theory and practice of medicine in the University of Leyden, where he taught with such eclat, and drew after him so great a number of pupils, that Boerhaave alone surpassed him in this respect. It was he that first introduced the practice of giving clinical lectures in the hospitals, on the cases treated in the presence of the pupils. This admirable innovation has been productive of much benefit to medicine. He greatly promoted anatomical studies, and inspected, himself, a vast number of dead bodies. This is the more remarkable, because his own system, like that of Van Helmont, from whom it was borrowed, was quite independent of the structure of the parts.
Every thing was explained by him according to the principles of chemistry, as they were then understood. The celebrity of the university in which he taught, and the vast number of his pupils, contributed to spread this theory into every part of the world, and to give it an eclat which is really surprising, when we consider it with attention. But he possessed the talents just suited for securing the reception of his opinions by his pupils as infallible oracles, and of being the idol of the university. Yet it is melancholy to be obliged to add, that few persons ever more abused the favours of nature, or the advantages of situation and elocution.
To form a clear idea of the principles of this founder of iatro-chemistry, we have only to call to mind the ferments of Van Helmont, which constitute the foundation-stone of the whole system. We cannot, says he, conceive a single change in the mixture of the humours, which is not the consequence of fermentation; and yet he assigns to this fermentation conditions which are scarcely to be found united in the living body. Digestion, in his opinion, is a true fermentation produced by the application of a ferment. Like Van Helmont, he admits a triumvirate; but places it in the humours; the effervescence or fermentation of which enabled him to explain most of the functions of the body. Digestion is the result of the mixture of the saliva with the pancreatic juice and the bile, and the fermentation of these humours. The saliva, as well as the pancreatic juice, contains an acidulous salt easily recognised by the taste. Here Sylvius derives advantage from the experiments of Regnier de Graaf on the pancreatic juice, which he had constantly found acid.
Sylvius, who affirmed that the bile contained an alkali, united with an oil and a volatile spirit, supposes an effervescence from the union of the alkali of the bile with the acid of the pancreatic juice, and this fermentation he considered as the cause of digestion. By this fermentation the chyle is produced, which is nothing else than the volatile spirit of the food accompanied by an oil and an alkali, neutralized by a weak acid. The blood is more than completed (plus quam perficitur) in the spleen. It acquires its highest perfection by the addition of a certain quantity of vital spirits. The bile is not drawn from the blood in the liver, but pre-exists in the circulating fluid. It mixes with that fluid anew to be carried to the heart together with the lymph, equally mixed with the blood, and there it gives origin to a vital fermentation. In this way the blood becomes the centre of reunion of all the humours of the secretions, which mix together or separate, without the solids taking the smallest share in the operations. Indeed, so completely are the solids banished from the system of Sylvius that he attends to nothing whatever except the humours.
The formation and motion of the blood is explained by the fermentation of the oily volatile salt of the bile, and the dulcified acid of the lymph, which develops the vital heat, by which the blood is attenuated and becomes capable of circulating. This vital fire, quite different from ordinary fire is kept up in its turn by the uniform mixture of the blood. It attenuates the humours, not because it is heat but because it is composed of pyramids. This last notion is obviously borrowed from Descartes, just as the fermentation in the heart, as the cause of the motion of the blood, reminds us of the opinions of Van Helmont.
Sylvius explains the preparation of the vital spirits in the encephalos by distillation, and he finds a great resemblance between their properties and those of spirit of wine. The nerves conduct these spirits to the different parts, and they spread themselves in the substance of the organs to render them sensible. When they insinuate themselves into the glands the addition of the acid of the blood produces a liquid analogous to naphtha, which constitutes the lymph. Lymph, then, is a compound of the vital spirit and the acid of the blood. Milk is formed in the mammæ by the afflux of a very mild acid, which gives a white colour to the red humour of the blood.