It was while Dr. Cullen was a practitioner in Shotts that he formed a connexion with William, afterwards Doctor Hunter, the famous lecturer on anatomy in London, who was a native of the same part of the country as Cullen. These two young men, stimulated by genius, though thwarted by the narrowness of their circumstances, entered into a copartnery business, as surgeons and apothecaries, in the country. The chief object of their contract was to furnish the parties with the means of carrying on their medical studies, which they were not able to do separately. It was stipulated that one of them, alternately, should be allowed to study in whatever college he preferred, during the winter, while the other carried on the common business in his absence. In consequence of this agreement, Cullen was first allowed to study in the University of Edinburgh, for a winter. When it came to Hunter’s turn next winter, he rather chose to go to London. There his singular neatness in dissecting, and uncommon dexterity in making anatomical preparations, his assiduity in study, his mild manners, and easy temper, drew upon him the attention of Dr. Douglas, who at that time read lectures on anatomy and midwifery in the capital. He engaged him as his assistant, and he afterwards succeeded him in the same department with much honour to himself, and advantage to the public. Thus was dissolved a copartnership of perhaps as singular a kind as any that occurs in the annals of science. Cullen was not disposed to let any engagement with him prove a bar to his partner’s advancement in the world. The articles were abandoned, and Cullen and Hunter kept up ever after a friendly correspondence; though there is reason to believe that they never afterwards met.

It was while a country practitioner that young Cullen married a Miss Johnston, daughter of a neighbouring clergyman. The connexion was fortunate and lasting. She brought her husband a numerous family, and continued his faithful companion through all the alterations of his fortune. She died in the summer of 1786.

In the year 1746 Cullen, who had now taken the degree of doctor of medicine, was appointed lecturer on chemistry in the University of Glasgow; and in the month of October began a course on that science. His singular talent for arrangement, his distinctness of enunciation, his vivacity of manner, and his knowledge of the science which he taught, rendered his lectures interesting to a degree which had been till then unknown in that university: he was adored by the students. The former professors were eclipsed by the brilliancy of his reputation, and he had to encounter all those little rubs and insults that disappointed envy naturally threw in his way. But he proceeded in his career regardless of these petty mortifications; and supported by the public, he was more than consoled for the contumely heaped upon him by the ill nature and pitiful malignity of his colleagues. His practice as a physician increased every day, and a vacancy occurring in the chair in 1751, he was appointed by the crown professor of medicine, which put him on a footing of equality with his colleagues in the university. This new appointment called forth powers which he was not before known to possess, and thus served still further to increase his reputation.

At that time the patrons of the University of Edinburgh were eagerly bent on raising the reputation of their medical school, and were in consequence on the look out for men of abilities and reputation to fill their respective chairs. Their attention was soon drawn towards Cullen, and on the death of Dr. Plummer, in 1756, he was unanimously invited to fill the vacant chemical chair. He accepted the invitation, and began his academical career in the College of Edinburgh in October of that year, and here he continued during the remainder of his life.

The appearance of Dr. Cullen in the College of Edinburgh constitutes a memorable era in the progress of that celebrated school. Hitherto chemistry being reckoned of little importance, had been attended by very few students; when Cullen began to lecture it became a favourite study, almost all the students flocking to hear him, and the chemical class becoming immediately more numerous than any other in the college, anatomy alone excepted. The students in general spoke of the new professor with that rapturous ardour so natural to young men when highly pleased. These eulogiums were doubtless extravagant, and proved disgusting to his colleagues. A party was formed to oppose this new favourite of the public. His opinions were misrepresented, it was affirmed that he taught doctrines which excited the alarm of some of the most moderate and conscientious of his colleagues. Thus a violent ferment was excited, and some time elapsed before the malignant arts by which this flame had been blown up were discovered.

During this time of public ferment Cullen went steadily forward; he never gave an ear to the gossip brought him respecting the conduct of his colleagues, nor did he take any notice of the doctrines which they taught. Some of their unguarded strictures on himself might occasionally have come to his ears; but if it was so, he took no notice of them whatever; they seemed to have made no impression on him.

This futile attempt to lower his character being thus baffled, his fame as a professor, and his reputation as a physician, increased daily: nor could it be otherwise; his professional knowledge was always great, and his manner of lecturing singularly clear and intelligible, lively, and entertaining. To his patients his conduct was so pleasing, his address so affable and engaging, and his manner so open, so kind, and so little regulated by pecuniary considerations, that those who once applied to him for medical assistance could never afterwards dispense with it: he became the friend and companion of every family he visited, and his future acquaintance could not be dispensed with.

His private conduct to his students was admirable, and deservedly endeared him to every one of them. He was so uniformly attentive to them, and took so much interest in the concerns of those who applied to him for advice; was so cordial and so warm, that it was impossible for any one, who had a heart susceptible of generous emotions, not to be delighted with a conduct so uncommon and so kind. It was this which served more than any thing else to extend his reputation over every civilized quarter of the globe. Among ingenuous youth gratitude easily degenerates into rapture; hence the popularity which he enjoyed, and which to those who do not well weigh the causes which operated on the students must appear excessive.

The general conduct of Cullen to his students was this: with all such as he observed to be attentive and diligent he formed an early acquaintance, by inviting them by twos, by threes, and by fours at a time to sup with him; conversing with them at such times with the most engaging ease, entering freely with them into the subject of their studies, their amusements, their difficulties, their hopes and future prospects. In this way he usually invited the whole of his numerous class till he made himself acquainted with their private character, their abilities, and their objects of pursuit. Those of whom he formed the highest opinion were of course invited most frequently, till an intimacy was gradually formed which proved highly beneficial to them. To their doubts and difficulties he listened with the most obliging condescension, and he solved them to the utmost of his power. His library was at all times open for their accommodation: in short, he treated them as if they had been all his relatives and friends. Few men of distinction left the University of Edinburgh, in his time, with whom he did not keep up a correspondence till they were fairly established in business. This enabled him gradually to form an accurate knowledge of the state of medicine in every country, and the knowledge thus acquired put it in his power to direct students in the choice of places where they might have an opportunity of engaging in business with a reasonable prospect of success.

Nor was it in this way alone that he befriended the students in the University of Edinburgh. Remembering the difficulties with which he had himself to struggle in his younger days, he was at all times singularly attentive to the pecuniary wants of the students. From the general intimacy which he contracted with them he found no difficulty in discovering those whose circumstances were contracted, or who laboured under any pecuniary embarrassment, without being under the necessity of hurting their feelings by a direct inquiry. To such persons, when their habits of study admitted it, he was peculiarly attentive: they were more frequently invited to his house than others, they were treated with unusual kindness and familiarity, they were conducted to his library and encouraged by the most delicate address to borrow from it freely whatever books he thought they had occasion for; and as persons under such circumstances are often extremely shy, books were sometimes pressed upon them as a sort of task, the doctor insisting upon knowing their opinion of such and such passages which they had not read, and desiring them to carry the book home for that purpose: in short, he behaved to them as if he had courted their company. He thus raised them in the opinion of their acquaintances, which, to persons in their circumstances, was of no little consequence. They were inspired at the same time with a secret sense of dignity, which elevated their minds, and excited an uncommon ardour, instead of that desponding inactivity so natural to depressed circumstances. Nor was he less delicate in the manner of supplying their wants: he often found out some polite excuse for refusing to take money for a first course, and never was at a loss for one to an after course. Sometimes (as his lectures were never written) he would request the favour of a sight of their notes, if he knew that they were taken with care, in order to refresh his memory. Sometimes he would express a wish to have their opinion of a particular part of his course, and presented them with a ticket for the purpose. By such delicate pieces of address, in which he greatly excelled, he took care to anticipate their wants. Thus he not only gave them the benefit of his own lectures, but by refusing to take money enabled them to attend such others as were necessary for completing their course of medical study.