Santonine.—An instance of an urticarial outbreak with oedema of the eyelids and swelling of the face has been observed following the ingestion of this drug.
Stramonium,—An erythematous efflorescence has been recorded as following this drug.
Strychnia.—A case is on record in which a rash of a scarlatinoid type followed a dose of one-twenty-fourth of a grain of strychnia.
Turpentine.—Both erythematous and papular eruptions, usually itchy, have appeared as the result of large doses of turpentine, occurring principally about the face and upper trunk, the papules being minute in character. A vesicular eruption has also been noticed somewhat similar to vesicular eczema.
DERMATITIS FACTITIA.—Feigned diseases of the skin are not uncommon. Erythema, vesicles, bullæ, and gangrene have been brought about, chiefly in hysterical females, to gain sympathy, or, as also in other individuals, for the purpose of deception, by the action of friction, acids, or strong alkalies.
Dermatitis Gangrænosa.
Dermatitis gangrænosa, or gangrene of the skin, is a rare affection. It may be idiopathic or symptomatic. As an idiopathic disease it begins usually as circular, erythematous, dark-red spots, tending to appear symmetrically, either painful and hyperæsthetic or without sensation. Malaise, fever, and symptoms of debility usually precede and accompany its development. The lesions go on to gangrene and sloughing, recovery taking place or a fatal termination gradually resulting. There may be several or as many as thirty or forty patches. The progress of the disease, whether terminating fatally or in recovery, is slow, usually of several months' duration. Gangrene of the skin as a symptomatic affection is occasionally seen in grave cerebral and spinal diseases, and also in diabetes.
Furunculus.
Furunculus, or boil, is a deep-seated, inflammatory disease, characterized by one or more variously-sized, circumscribed, rounded, more or less acuminated, firm, painful formations, usually terminating in central suppuration.
In the beginning the lesion appears as a reddish spot, small, rounded, imperfectly defined, inflammatory, and painful to the touch, having its seat in the corium; it gradually becomes larger, raised, and with marked tendency to central suppuration, usually maturing in from one to two weeks, when it appears as a painful, deep-red, rounded, pointed, inflammatory formation, varying in size from a pea to a walnut, exhibiting central suppuration, the so-called core. In some cases there is no tendency to core-formation, such lesions being popularly designated blind boils.