| No. | Year. | Name of Author and Patient. | Age at time of Paralysis. | Age at time of Autopsy. | Nature of Symptoms. | Limbs Paralyzed. | Result of Autopsy. | Reference in Literature. |
| 16 | 1866 | Prévost. | ? | 78 | ? | L. u. | Atrophy of left anterior cornu, especially of
ganglion-cells. | Comptes Rendus, Soc. Biol., Gaz. méd.,
1866. |
| 17 | 1870 | Charcot and Joffroy. | 7 | 32 | Sudden. | All esp. l. u. | Atrophy of cells ant. horns and ant. lateral
columns. | Archives de Phys., 1870. |
| 18 | 1870 | Parrot and Joffroy. | — | 3 | Unknown. | B. l. | Atrophy and partial sclerosis of anterior
cornua and ant. lat. columns. | |
| 19 | 1870 | Vulpian. | ? | 66 | ? | L. l. | Atrophy of ganglion-cells, sclerosis of
antero-lateral columns. | Archives Physiol., 1870. |
| 20 | 1871 | Müller. | 4 | 34 | Fall from bed. | L. lower. | Atrophy of ganglion-cells ant. cornua;
sclerosis of anterior roots. | Quoted by Seeligmüller, Gerhardt's
Handbuch, Tabeln. |
| 21 | 1873 | Lancereaux and Pierret. | 2 | 18 | ? | L. upper. | Atrophy of external group cells in ant.
cornua; general atrophy of left half of lumbar cord. | Petitfils, Thesis on Atrophie aigue des
Cellules motrices, 1873, p. 33. |
| 22 | 1875 | Raymond. | ? | 75 | ? | R. arm. | Atrophy of ganglion-cells in right ant. horn
cerv. region. | Gaz. méd de Paris, No. 19, 1875. |
| 23 | 1879 | Taylor. | 1½ | 3 | 3 days' fever. | L. leg. | Atrophy of left ant. cornua; disappearance of
ganglion-cells; no lesion in white column. | Trans. Path. Soc. London, 1879. |
| 24 | 1875 | Dejerine. | — | — | — | R. foot (congenital equinus). | Atrophy of ant. horn right side; atrophy
external group of motor-cells. | Arch. Phys., 1874. |
| 25 | 1879 | Humphreys. | 1½ | 3½ | ? | L. leg. | Atrophy of left half lumbar cord;
disappearance of medial group cells both sides; antero-lateral on left
side. | Trans. Path. Soc. London, 1879. |
In the remaining cases the ganglion-cells of the anterior cornua had also disappeared; but in addition to this atrophy excited distinct evidence of more or less extensive inflammation. This table includes one case of autopsy at two months (Roger's); one at six weeks after paralysis (Turner's).
TABLE V.—AUTOPSIES SHOWING EVIDENCE OF MYELITIS, TO WHICH THE ATROPHY OF THE GANGLION-CELLS WAS CONSECUTIVE.
| No. | Year. | Name of Author and Patient. | Age at time of Paralysis. | Age at time of Autopsy. | Nature of Symptoms. | Limbs Paralyzed. | Appearance at Autopsy. | Reference in Literature. |
| 26 | 1866 | Echeverria. | 3 | 10 | Fever. | R. arm, R. leg. | Granular pigmentation anterior cornua, diffuse
myelitis. | Quoted by Seguin, loc. cit. |
| 27 | 1866 | Echeverria. | 2 | 2½ | Febrile diarrhœa. | Both legs. | Ibid. | Ibid. |
| 28 | 1871 | Roger and Damaschino. | 15/6 | 2 | Scarlatina with second attack. | L. arm, then both legs. | Foci of softening throughout cord. Atrophy
ganglion-cells and nerve-fibres. Dilatation, fatty degen. vessels.
Sclerosis ant. columns. Atrophy ant. roots. | Gaz. méd. de Paris, 1871. |
| 29 | 1871 | Roger and Damaschino. | 2 | 2½ | Variola. | Both legs. | Foci of softening in ant. cornua. Fatty degen.
blood-vessels, circumscribed myelitis. | Ibid. |
| 30 | 1871 | Roger and Damaschino. | 2 | 3 | Fever. | Ibid. | Foci of softening, as above. | Ibid. |
| 31 | 1873 | Roth. | 1 | 2 | Ibid. | Ibid. | Focus myelitis on both sides. Disappearance
ganglion-cells, abundant exudation corpuscles. | Virch. Arch., 1873, Bd. lviii. |
| 32 | 1868 | L. Clarke. | 1 | 32 | After inoculation. | Both arms. | Extensive myelitis ant. and central part gray
matter. Disappearance ganglion-cells. | Med.-Chir. Trans., li. p. 219. |
| 33 | 1876 | Schultze. | 3 | 22 | Acute disease. | Both legs. | Atrophy lumbar cord ant. lat. columns. Atrophy
ganglion-cells. Abundant exud. corpuscles. Proliferation neuroglia. | Virch. Archiv, Bd. lxviii., 1876. |
| 34 | 1876 | Leyden. | 2 | 60 | Fall from table. | L. leg. | Circumscribed cicatrix with complete
destruction gray substance. Amyloid degeneration. Atrophy ant. roots. | Archiv f. Psych., 1876, Bd. vi. |
| 35 | 1876 | Leyden. | ¾ | 1¾ | Suddenly. | L. leg. | Atrophy ganglion-cells. Cellular diffused
infilt. (myelitis) gray subst'ce. | Ibid. |
| 36 | 1876 | Leyden. | 4 | 58 | Sudden over night. | L. leg. | Amyloid infiltration ant. horns, atrophy
ganglion-cells left lumbar horn. Diffuse atrophy gray substance. | Ibid. |
| 37 | 1876 | Leyden. | 3 | 20 | Ibid. | R. leg, L. arm. | Sclerotic focus in right lumbar and in left
cerv. region. Diffuse meningo-myelitis. Atrophy ant. lat. columns.
Encapsulated myelitis. | Ibid. |
| 38 | 1876 | Demme. | ? | 3½ | ? | — | Purulent focus in ant. cornua lumbar region.
Atrophy ganglion-cells. | Quoted by Seeligmüller, loc. cit., p. 18. |
| 39 | 1876 | Eisenlohr. | ? | ¾ | ? | B. legs. | Diffuse inflammation anterior horns and ant.
lat. columns. | Ibid. |
| 40 | 1879 | Turner. | 2½ | 2¾ | ? | | Myelitic disorganization gray substance ant.
cornua lumbar cord. | Trans. Path. Soc. Lond., 1879. |
| 41 | 1883 | Archambault et Damaschino. | 30 m's | 31 m's, or 26 d'ys fr.
début. | Malaise and prostration one day. | Left leg and right arm. | Focus red softening ant. horns left lumbar;
right cervical region. Enormous enlargement vascular network, and
distension blood-vessels; granular corpuscles in lymphatic sheaths;
marked atrophy cells and of myeline sheaths of fibres in ant. roots;
myeline balls in sheath; axis-cylinders disappeared. Lesions more or
less marked throughout cord. Nerves not examined. | Le Union médicale, 1883. |
| 42 | 1884 | Money. | 2 yrs. | 28 m's. | Fever and vomiting for a week. | Paraplegia. | Red area both anterior cornua lumbar region.
Here distension and thrombosis vessels; infiltration leucocytes;
absence multipolar cells. | Trans. Path. Soc. Lond., 1884. |
| | 1884 | Money. | Unknown | 7 yrs. | Unknown. | Right leg. | Wasting anterior horn almost throughout lumbar
region. Atrophy cells chiefly in ant., ant.-lat., post.-lateral, and
central groups, replaced by dense nucleated tissue. | |
It will be useful to add another table, which will group together the cases in which the autopsies were made within two years after the occurrence of the paralysis. Of these, all but the two made by Laborde, in which the cornua are declared to be healthy and the lesion limited to the white columns, show traces of destructive morbid processes in the gray substance of the cord, greatly predominating in the anterior cornua, but not absolutely limited to them, nor even to the part of the cord which corresponds to the paralyzed limb:
TABLE VI.
AUTOPSIES OF RELATIVELY RECENT CASES.—In cases relatively recent all macroscopic changes in the cord may be entirely wanting. There may be some degree of asymmetry in the surface of section, patches of white coloration in the anterior gray substance, or of gray or yellow color in the white columns; the anterior roots may be congested or even already atrophied.94 On the other hand, there have several times been found foci of visible red softening, much more frequently at a point corresponding to the origin of the paralyzed nerves, but not absolutely confined to them, and sometimes existing at points where they have given rise to no symptoms whatever.95