Subsequent to Theodoric’s time, we find many interesting and suggestive observations in the writings of Baptista Porta, Chamappe, Meissner, Dauriol, Haller, and Blandin. About half a century ago, Sir Humphry Davy thus hinted at the possibility that a pain subduing gas might be inhaled:—“As nitrous oxide, in its extensive operation, appears capable of destroying physical pain, it may probably be used with advantage during surgical operations in which no great effusion of blood takes place.” Baron Larrey, Napoleon’s surgeon, after the battle of Eylau, found a remarkable insensibility in the wounded who suffered amputations, owing to the intense cold. This fact afterwards led to the application of ice as a local anæsthetic.

The former general belief that a degree of anæsthetic and prolonged sleep could be induced artificially by certain medicated potions and preparations is also shown by the frequency with which the idea is alluded to by the older poets and storytellers, and made part of the machinery in the popular romance and drama. In the history of Taliesin, (one of the antique Welsh tales contained in the Mabinogion,) Rhun is described as having put the maid of the wife of Elphin into a deep sleep with a powder put into her drink, and as having cut off one of her fingers when she was in this case of artificial anæsthesia. Shakspeare, besides alluding more than once to the soporific property of mandragora, describes with graphic power in Romeo and Juliet, and in Cymbeline, the imagined effects of subtle distilled potions supposed capable of inducing, without danger, a prolonged state of death-like sleep or lethargy. And Thomas Middleton, in his tragedy of Women beware Women, published in 1657, pointedly and directly alludes in the following lines, to the practice of anæsthesia in ancient surgery:—

Hippolito. Yes, my lord,

I make no doubt, as I shall take the course,

Which she shall never know till it be acted;

And when she wakes to honor, then she’ll thank me for’t.

I’ll imitate the pities of old surgeons

To this lost limb; who, ere they show their art,

Cast one asleep, then cut the diseased part;

So out of love to her I pity most,